Mavrogenis Andreas F, Rossi Giuseppe, Calabrò Teresa, Altimari Guglielmo, Rimondi Eugenio, Ruggieri Pietro
Department of Orthopaedics, Orthopaedic Oncology Service, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy.
Musculoskelet Surg. 2012 Aug;96(2):125-35. doi: 10.1007/s12306-012-0207-2. Epub 2012 Jun 9.
We retrospectively studied 31 patients with painful bone (15 patients) and soft-tissue (16 patients) hemangiomas treated with 39 embolizations using N-2-butyl cyanoacrylate from 2003 to 2010. The mean tumor size before embolization was 6 cm for bone and 7 cm for soft-tissue hemangiomas. The technique of embolization was the same for bone and soft-tissue lesions. Preoperative embolization was done in six patients, while the remaining patients had embolization as only treatment. The mean follow-up was 47 months (11-89 months). The clinical and imaging effect of treatment was evaluated at follow-up with a pain score scale, tumor size, and ossification. In four patients, embolization was not feasible because of the inability to catheterize and low blood flow of the feeding vessels. Nine patients with bone and 10 with soft-tissue hemangiomas experienced complete pain relief. Four patients with bone and four with soft-tissue hemangiomas experienced recurrence of pain and were treated with repeat embolization. Re-recurrences were not observed in any of the patients with soft-tissue hemangiomas until the period of this study. Ossification and tumor size reduction were higher for bone hemangiomas. Embolization-related complications were more common for soft-tissue hemangiomas.
我们回顾性研究了2003年至2010年间31例患有疼痛性骨（15例）和软组织（16例）血管瘤的患者，这些患者接受了39次使用N-2-氰基丙烯酸正丁酯的栓塞治疗。栓塞前骨血管瘤的平均肿瘤大小为6厘米，软组织血管瘤为7厘米。骨和软组织病变的栓塞技术相同。6例患者进行了术前栓塞，其余患者仅接受栓塞治疗。平均随访时间为47个月（11 - 89个月）。随访时通过疼痛评分量表、肿瘤大小和骨化情况评估治疗的临床和影像学效果。4例患者因无法插管和供血血管血流低而无法进行栓塞。9例骨血管瘤患者和10例软组织血管瘤患者疼痛完全缓解。4例骨血管瘤患者和4例软组织血管瘤患者疼痛复发并接受了重复栓塞治疗。在本研究期间，软组织血管瘤患者均未出现再次复发。骨血管瘤的骨化和肿瘤缩小程度更高。栓塞相关并发症在软组织血管瘤中更常见。
