Chen Dingyan, Liu Yan, He Wulong, Wang Hongxing, Wang Zengzhen
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Compulsory Detoxification Treatment Center, Wuhan Public Security Bureau, Wuhan, 430040, China.
J Huazhong Univ Sci Technolog Med Sci. 2012 Jun;32(3):422-427. doi: 10.1007/s11596-012-0073-z. Epub 2012 Jun 9.
This study examined the effects of combined administration of tyrosine, lecithin, L-glutamine and L-5-hydroxytryptophan (5-HTP) on heroin withdrawal syndromes and mental symptoms in detoxified heroin addicts. In the cluster-randomized placebo-controlled trial, 83 detoxified heroin addicts were recruited from a detoxification treatment center in Wuhan, China. Patients in the intervention group (n=41) were given the combined treatment with tyrosine, lecithin, L-glutamine and 5-HTP and those in the control group (n=42) were administered the placebo. The sleep status and the withdrawal symptoms were observed daily throughout the study, and the mood states were monitored pre- and post-intervention. The results showed that the insomnia and withdrawal scores were significantly improved over time in participants in the intervention group as compared with those in the control group. A greater reduction in tension-anxiety, depression-dejection, anger-hostility, fatigue-inertia and total mood disturbance, and a greater increase in their vigor-activity symptoms were found at day 6 in the intervention group than in the control group (all P<0.05). It was concluded that the neurotransmitter-precursor-supplement intervention is effective in alleviating the withdrawal and mood symptoms and it may become a supplementary method for patients' recovery from heroin addiction.
本研究考察了联合使用酪氨酸、卵磷脂、L-谷氨酰胺和L-5-羟色氨酸（5-HTP）对戒毒后海洛因成瘾者戒断综合征及精神症状的影响。在这项整群随机安慰剂对照试验中，从中国武汉的一家戒毒治疗中心招募了83名戒毒后的海洛因成瘾者。干预组（n = 41）的患者接受了酪氨酸、卵磷脂、L-谷氨酰胺和5-HTP的联合治疗，对照组（n = 42）的患者则服用安慰剂。在整个研究过程中，每天观察睡眠状况和戒断症状，并在干预前后监测情绪状态。结果显示，与对照组相比，干预组参与者的失眠和戒断评分随时间显著改善。干预组在第6天时，紧张焦虑、抑郁沮丧、愤怒敌意、疲劳惰性和总体情绪紊乱的减轻程度更大，活力活动症状的增加幅度也更大，均优于对照组（所有P<0.05）。研究得出结论，神经递质前体补充干预在减轻戒断和情绪症状方面有效，可能成为帮助海洛因成瘾患者康复的一种辅助方法。
