Guan Shi-Jie, Yan Xiao-Ping, Lin Jing-Kai
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Mar;32(3):398-401.
To study the acute toxicity of the water extracts (ERWE) and 60% ethanol extracts (EREE) from different processed products of Radix Polygalae (crude Radix Polygalae, licorice, and honey processed Radix Polygalae), thus providing scientific evidence for toxicity study of Radix Polygalae and its safe clinical application.
The ERWE and EREE were prepared from different processed products of Radix Polygalae. Their contents of saponins were respectively determined. The poisoning condition and death of the mice administered with ERWE and EREE by gastrogavage were observed within fourteen days. The modified Karber's method was used to calculate LD50 and 95% confidence interval (CI).
The EREE of licorice processed Radix Polygalae had the maximum toxicity with highest content of saponins, while the ERWE of honey processed Radix Polygalae had the minimum toxicity with lowest content of saponins.
Different processing methods have effects on the contents of saponins in Radix Polygalae. The experiment showed that the toxicity of Radix Polygalae is in direct proportion to the content of saponins. The higher the saponins contents, the higher the toxicity.
研究远志不同炮制品（生远志、甘草制远志和蜜制远志）水提取物（ERWE）和60%乙醇提取物（EREE）的急性毒性，为远志的毒性研究及其临床安全应用提供科学依据。
制备远志不同炮制品的ERWE和EREE，分别测定其皂苷含量。观察灌胃给予ERWE和EREE的小鼠在14天内的中毒情况和死亡情况。采用改良寇氏法计算半数致死量（LD50）及95%可信区间（CI）。
甘草制远志的EREE皂苷含量最高，毒性最大；蜜制远志的ERWE皂苷含量最低，毒性最小。
不同炮制方法对远志中皂苷含量有影响。实验表明，远志的毒性与皂苷含量成正比。皂苷含量越高，毒性越大。
