Department of Dermatology and Venereology, Karolinska Hospital and Institute of Medicine, Karolinska Institutet, Stockholm, Sweden.
Acta Derm Venereol. 2013 Mar 27;93(2):223-7. doi: 10.2340/00015555-1375.
There have been a number of Swedish studies on human papillomavirus (HPV) typing in men, most of which have used less sensitive HPV-typing techniques. The present study included male patients with genital HPV-induced lesions planned for surgery. Samples were prepared for histopathology and PCR. HPV was detected in 233/253 (92%) and HPV 6 or 11 in 89% of the HPV-positive lesions. There were statistically significant differences regarding morphology (p=0.002), location (p=0.000001) and colour (p=0.005) of the lesions for low- vs. mixed or high-risk HPV types. For example, acuminate lesions were mostly found among men with low-risk HPV types, whereas macular lesions were over-represented among them with mixed or high-risk types. The HPV type distribution is similar to that in earlier studies, but we also found correlations with some clinical parameters.
已经有一些瑞典的关于人类乳头瘤病毒（HPV）在男性中的类型研究，其中大部分使用的 HPV 类型检测技术敏感性较低。本研究包括计划手术治疗的男性生殖器 HPV 感染引起的病变患者。样本制备用于组织病理学和 PCR 检测。在 253 例 HPV 阳性病变中，233 例（92%）检测到 HPV，HPV 6 或 11 型在 89%的 HPV 阳性病变中检测到。低危型 HPV 与混合或高危型 HPV 相比，病变的形态（p=0.002）、位置（p=0.000001）和颜色（p=0.005）有统计学显著差异。例如，低危型 HPV 感染的男性中，尖锐湿疣样病变多见，而混合或高危型 HPV 感染的男性中，斑块状病变多见。HPV 类型的分布与早期研究相似，但我们也发现了与一些临床参数的相关性。
