Wikström Arne, Hedblad Mari-Anne, Syrjänen Stina
Department of Dermatology & Venereology, Karolinska Hospital and Institute of Medicine, Karolinska Institute, Stockholm, Sweden.
Int J STD AIDS. 2013 Dec;24(12):938-43. doi: 10.1177/0956462413487325. Epub 2013 Jul 19.
The purpose of this study was to analyse, among men treated with diathermy, whether there was a difference in balanoposthitis between men with histopathologically benign human papillomavirus-associated lesions and those with penile intraepithelial neoplasia. Data were derived from patient material from a previously published study. Two clinically identical lesions from the same genital site were collected for analysis with routine histopathology and with nested PCR. In total, 292 men were included, of which 47 (16%) had penile intraepithelial neoplasia. Of those with penile intraepithelial neoplasia, 19/47 (40%) reported problems consistent with balanoposthitis, compared with only 15/245 (6%) patients with benign lesions (p < 0.0001). A statistical difference in percentage distribution was also seen regarding morphology (p = 0.001) and location (p = 0.0003) of the lesions among the men having benign lesions with and without balanoposthitis. It is not possible to take biopsies from patients with genital warts, but this study suggests that one probably should be more observant for genital dysplasia among those men with warts with a history of balanoposthitis than those with no such history.
本研究的目的是分析在接受透热疗法治疗的男性中，组织病理学上与人乳头瘤病毒相关的良性病变男性与阴茎上皮内瘤变男性之间在龟头炎方面是否存在差异。数据来源于之前发表的一项研究中的患者资料。从同一生殖器部位采集两个临床相同的病变组织，用于常规组织病理学分析和巢式聚合酶链反应。总共纳入了292名男性，其中47名（16%）患有阴茎上皮内瘤变。在患有阴茎上皮内瘤变的患者中，19/47（40%）报告有与龟头炎相符的问题，而在良性病变患者中只有15/245（6%）有此类问题（p<0.0001）。在有和没有龟头炎的良性病变男性中，病变的形态（p = 0.001）和位置（p = 0.0003）在百分比分布上也存在统计学差异。对于患有尖锐湿疣的患者无法进行活检，但本研究表明，对于有龟头炎病史的尖锐湿疣男性，可能比没有此类病史的男性更应密切关注生殖器发育异常情况。
