蛋白激酶 C 同工型的心脏作用。
Cardiac actions of protein kinase C isoforms.
机构信息
Department of Pharmacology, Columbia University, New York, New York, USA.
出版信息
Physiology (Bethesda). 2012 Jun;27(3):130-9. doi: 10.1152/physiol.00009.2012.
Abstract
Protein kinase C (PKC) isoforms have emerged as important regulators of cardiac contraction, hypertrophy, and signaling pathways that influence ischemic/reperfusion injury. This review focuses on newer concepts regarding PKC isoform-specific activation mechanisms and actions that have implications for the development of PKC-targeted therapeutics.
摘要
蛋白激酶 C（PKC）同工型已成为影响缺血/再灌注损伤的心脏收缩、肥大和信号转导途径的重要调节因子。本文综述了关于 PKC 同工型特异性激活机制和作用的新概念，这些概念对 PKC 靶向治疗的发展具有重要意义。
相似文献
1
Cardiac actions of protein kinase C isoforms.蛋白激酶 C 同工型的心脏作用。
Physiology (Bethesda). 2012 Jun;27(3):130-9. doi: 10.1152/physiol.00009.2012.
2
Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats.Dahl盐敏感大鼠心脏肥大期和充血性心力衰竭期蛋白激酶C亚型的差异诱导
Hypertens Res. 2003 May;26(5):421-6. doi: 10.1291/hypres.26.421.
3
The alpha(1)-adrenoceptor subtype- and protein kinase C isoform-dependence of Norepinephrine's actions in cardiomyocytes.去甲肾上腺素在心肌细胞中作用的α(1)-肾上腺素能受体亚型和蛋白激酶C同工型依赖性
J Mol Cell Cardiol. 2000 Jul;32(7):1193-209. doi: 10.1006/jmcc.2000.1153.
4
Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity.缺血预处理可诱导清醒家兔心脏中蛋白激酶C同工型ε和η的选择性易位，而总蛋白激酶C活性无亚细胞再分布。
Circ Res. 1997 Sep;81(3):404-14. doi: 10.1161/01.res.81.3.404.
5
Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure.导致心脏肥大和心力衰竭进展的蛋白激酶C亚型选择性信号。
Mol Cell Biochem. 2003 Sep;251(1-2):97-101.
6
Activated protein kinase C isoforms target to cardiomyocyte caveolae : stimulation of local protein phosphorylation.活化的蛋白激酶C亚型定位于心肌细胞小窝：刺激局部蛋白磷酸化。
Circ Res. 1999 May 14;84(9):980-8. doi: 10.1161/01.res.84.9.980.
7
Activation of mitochondrial ATP-sensitive K(+) channel for cardiac protection against ischemic injury is dependent on protein kinase C activity.线粒体ATP敏感性钾通道激活对心脏缺血性损伤的保护作用依赖于蛋白激酶C活性。
Circ Res. 1999 Oct 15;85(8):731-41. doi: 10.1161/01.res.85.8.731.
8
Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1.蛋白激酶Cε诱导的心力衰竭中增强的蛋白激酶CβII易位及蛋白激酶CβII与1型蛋白激酶C受体的相互作用：1型蛋白激酶C受体的作用
Am J Physiol Heart Circ Physiol. 2001 Dec;281(6):H2500-10. doi: 10.1152/ajpheart.2001.281.6.H2500.
9
Nitric oxide mediates protein kinase C isoform translocation in rat heart during postischemic reperfusion.一氧化氮介导大鼠心脏缺血再灌注过程中蛋白激酶C亚型的易位。
Biochim Biophys Acta. 1999 Feb 24;1453(2):230-8. doi: 10.1016/s0925-4439(98)00105-7.
10
Implication of protein kinase C-alpha, delta, and epsilon isoforms in ischemic preconditioning in perfused rat hearts.蛋白激酶C-α、δ和ε亚型在灌注大鼠心脏缺血预处理中的作用
J Biochem. 1997 Sep;122(3):506-11. doi: 10.1093/oxfordjournals.jbchem.a021781.
引用本文的文献
1
Desmoplakin loss leads to PKC-dependent insertion of series sarcomeres and contractile dysfunction in cardiomyocytes.桥粒斑蛋白缺失导致蛋白激酶C依赖性串联肌节插入及心肌细胞收缩功能障碍。
bioRxiv. 2025 May 19:2025.05.15.654389. doi: 10.1101/2025.05.15.654389.
2
D389V Variant Induces Hypercontractility in Cardiac Organoids.D389V 变异导致心脏类器官过度收缩。
Cells. 2024 Nov 19;13(22):1913. doi: 10.3390/cells13221913.
3
An Update on Protein Kinases as Therapeutic Targets-Part I: Protein Kinase C Activation and Its Role in Cancer and Cardiovascular Diseases.蛋白激酶作为治疗靶点的最新研究进展——第一部分：蛋白激酶 C 的激活及其在癌症和心血管疾病中的作用。
Int J Mol Sci. 2023 Dec 18;24(24):17600. doi: 10.3390/ijms242417600.
4
Oral angiotensin-converting enzyme inhibitor captopril protects the heart from Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice.口服血管紧张素转换酶抑制剂卡托普利可保护心脏免受牙龈卟啉单胞菌 LPS 诱导的小鼠心功能障碍。
PLoS One. 2023 Nov 20;18(11):e0292624. doi: 10.1371/journal.pone.0292624. eCollection 2023.
5
Effects of the angiotensin-converting enzyme inhibitor captopril on occlusal-disharmony-induced cardiac dysfunction in mice.血管紧张素转换酶抑制剂卡托普利对咬合失调诱导的小鼠心功能障碍的影响。
Sci Rep. 2023 Nov 15;13(1):19927. doi: 10.1038/s41598-023-43099-6.
6
Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis.细胞外组蛋白诱导的蛋白激酶 Cα激活和肌钙蛋白磷酸化是脓毒症心肌收缩力抑制的潜在机制。
Int J Mol Sci. 2023 Feb 6;24(4):3225. doi: 10.3390/ijms24043225.
7
Cardiac Metabolism and MiRNA Interference.心脏代谢与 miRNA 干扰
Int J Mol Sci. 2022 Dec 20;24(1):50. doi: 10.3390/ijms24010050.
8
Lipid-independent activation of a muscle-specific PKCα splicing variant.肌肉特异性 PKCα 剪接变异体的无脂依赖性激活。
Am J Physiol Heart Circ Physiol. 2022 Oct 1;323(4):H825-H832. doi: 10.1152/ajpheart.00304.2022. Epub 2022 Sep 16.
9
Analyzing the Systems Biology Effects of COVID-19 mRNA Vaccines to Assess Their Safety and Putative Side Effects.分析新冠mRNA疫苗的系统生物学效应以评估其安全性和潜在副作用。
Pathogens. 2022 Jun 29;11(7):743. doi: 10.3390/pathogens11070743.
10
Early Protective Role of Inflammation in Cardiac Remodeling and Heart Failure: Focus on TNFα and Resident Macrophages.炎症在心脏重构和心力衰竭中的早期保护作用：聚焦于 TNFα 和驻留巨噬细胞。
Cells. 2022 Apr 6;11(7):1249. doi: 10.3390/cells11071249.
本文引用的文献
1
Insulin promotes neuronal survival via the alternatively spliced protein kinase CδII isoform.胰岛素通过剪接变异的蛋白激酶 CδII 异构体促进神经元存活。
J Biol Chem. 2012 Mar 16;287(12):9299-310. doi: 10.1074/jbc.M111.313080. Epub 2012 Jan 24.
2
Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K).蛋白激酶 C 诱导的磷酸化磷脂酰肌醇 3-激酶（PI3K）的 p85 亚基抑制内皮细胞中的胰岛素信号转导。
J Biol Chem. 2012 Feb 10;287(7):4518-30. doi: 10.1074/jbc.M111.286591. Epub 2011 Dec 12.
3
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains.丝氨酸磷酸化 PI3K 调节亚基 p85alpha Src 同源-2 结构域抑制 PI3K 与激活剂的结合。
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14157-62. doi: 10.1073/pnas.1107747108. Epub 2011 Aug 8.
4
Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription.钙蛋白酶生成的无活性催化结构域诱导的受体非依赖性蛋白激酶 Cα（PKCalpha）信号转导导致组蛋白去乙酰化酶 5 核输出并调节心脏转录。
J Biol Chem. 2011 Jul 29;286(30):26943-51. doi: 10.1074/jbc.M111.234757. Epub 2011 Jun 3.
5
Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.肾小球特异性蛋白激酶 C-β诱导的糖尿病和肥胖大鼠模型中胰岛素受体底物-1功能障碍和胰岛素抵抗。
Kidney Int. 2011 Apr;79(8):883-96. doi: 10.1038/ki.2010.526. Epub 2011 Jan 12.
6
Protein kinase D isoforms are activated in an agonist-specific manner in cardiomyocytes.蛋白激酶 D 同工型在心肌细胞中以激动剂特异性方式激活。
J Biol Chem. 2011 Feb 25;286(8):6500-9. doi: 10.1074/jbc.M110.208058. Epub 2010 Dec 14.
7
Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains.钙蛋白酶介导的调节结构域截断导致受体非依赖性心肌蛋白激酶 Calpha 的激活。
Circ Res. 2010 Oct 1;107(7):903-12. doi: 10.1161/CIRCRESAHA.110.220772. Epub 2010 Aug 5.
8
Protein kinase C-{delta} regulates the subcellular localization of Shc in H2O2-treated cardiomyocytes.蛋白激酶 C-δ调节 H2O2 处理的心肌细胞中 Shc 的亚细胞定位。
Am J Physiol Cell Physiol. 2010 Oct;299(4):C770-8. doi: 10.1152/ajpcell.00170.2010. Epub 2010 Aug 4.
9
Vitamin A metabolite, all-trans-retinoic acid, mediates alternative splicing of protein kinase C deltaVIII (PKCdeltaVIII) isoform via splicing factor SC35.维生素 A 代谢物全反式视黄酸通过剪接因子 SC35 介导蛋白激酶 C δVIII（PKCδVIII）同工型的选择性剪接。
J Biol Chem. 2010 Aug 20;285(34):25987-95. doi: 10.1074/jbc.M110.100735. Epub 2010 Jun 14.
10
G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C.机械牵张刺激通过 Gαq 介导激活心肌细胞中的 GRK2：蛋白激酶 C 的作用。
J Biol Chem. 2010 Apr 30;285(18):13748-60. doi: 10.1074/jbc.M110.109272. Epub 2010 Mar 1.
Zotero 插件