Rudolph C, Richards G E, Kaplan S, Ganong W F
Neuroendocrinology. 1979;29(3):169-77. doi: 10.1159/000122919.
In pentobarbital-anesthetized dogs, infusion of a low dose of histamine directly into the third ventricle increased plasma ACTH concentration. The increase was unaffected by metiamide, a drug which blocks H2 receptors, but was abolished by mepyramine, a drug which blocks H1 receptors. Mepyramine alone did not produce a decrease in plasma ACTH concentration in stressed dogs. Infusion of the H1 agonist 2-methylhistamine increased plasma ACTH concentration, whereas infusion of the H2 agonist 4-methylhistamine decreased plasma ACTH concentration and blocked the response to surgical stress. Histamine, 2-methylhistamine and 4-methylhistamine had no statistically significant effect on plasma renin activity, blood pressure, or heart rate, and histamine had no effect on plasma prolactin concentration. There were no consistent, specific effects on growth hormone secretion. We conclude that activation of central H1 receptors increases ACTH secretion in dogs, and that activation of central H2 receptors decreases ACTH secretion. Some of the reported effects of cyproheptadine and other drugs on ACTH secretion may be due to their antihistamine activity.
在戊巴比妥麻醉的犬中，将低剂量组胺直接注入第三脑室会增加血浆促肾上腺皮质激素（ACTH）浓度。这种增加不受甲硫咪胺（一种阻断H2受体的药物）的影响，但被吡苄明（一种阻断H1受体的药物）消除。单独使用吡苄明不会使应激犬的血浆ACTH浓度降低。注入H1激动剂2-甲基组胺会增加血浆ACTH浓度，而注入H2激动剂4-甲基组胺会降低血浆ACTH浓度并阻断对手术应激的反应。组胺、2-甲基组胺和4-甲基组胺对血浆肾素活性、血压或心率没有统计学上的显著影响，组胺对血浆催乳素浓度也没有影响。对生长激素分泌没有一致的、特异性的影响。我们得出结论，中枢H1受体的激活会增加犬的ACTH分泌，而中枢H2受体的激活会减少ACTH分泌。一些关于赛庚啶和其他药物对ACTH分泌的报道效应可能归因于它们的抗组胺活性。
