Wang Q Y, Huang D Z, He L X
Beijing second Infectious Diseases Hospital.
Zhonghua Nei Ke Za Zhi. 1990 Jun;29(6):332-5, 381.
To clarify the correlation of hepatitis D virus (HDV) infection and viral replication in liver diseases, the authors detected HDV RNA and serological HDV markers in serum from 285 patients with hepatitis B and 45 asymptomatic carriers of HBsAg. With dot blot hybridization, serum HDV RNA was detected in 8.8% (29/330) of the patients with HBV infection. The positive rate of HDV RNA in fulminant hepatitis was higher than that in benign hepatitis (15/74 vs 3/47, P less than 0.05). 10 of the 139 patients with chronic active hepatitis and 1 of the 6 cases with cirrhosis were positive for HDV RNA. However, all of the 19 cases with chronic persistent hepatitis and 45 asymptomatic carriers of HBsAg were negative fo, HDV RNA. Serological HDV markers, HDAgr anti-HD and IgM-anti-HD, were determined with ELISA. HDV RNA was detected in all of the serum samples with positive HDAg and/or IgM-anti-HD, in 15 of the 26 cases with positive-anti-HD and in 8 cases without HDV markers. Our results showed that 40 of the 330 patients with HBsAg were infected by HDV. This investigation suggests that HDV is one of the etiological factors for fulminant hepatitis and chronic active hepatitis.
为阐明丁型肝炎病毒（HDV）感染与肝脏疾病中病毒复制的相关性，作者检测了285例乙型肝炎患者和45例无症状HBsAg携带者血清中的HDV RNA及HDV血清学标志物。采用斑点杂交法，在330例HBV感染患者中，8.8%（29/330）检测到血清HDV RNA。暴发性肝炎中HDV RNA阳性率高于良性肝炎（15/74比3/47，P<0.05）。139例慢性活动性肝炎患者中有10例、6例肝硬化患者中有1例HDV RNA阳性。然而，19例慢性持续性肝炎患者及45例无症状HBsAg携带者的HDV RNA均为阴性。采用ELISA法检测HDV血清学标志物HDAg、抗-HD和IgM-抗-HD。在所有HDAg和/或IgM-抗-HD阳性的血清样本中、26例抗-HD阳性病例中的15例以及8例无HDV标志物的病例中均检测到HDV RNA。结果显示，330例HBsAg阳性患者中有40例感染了HDV。本研究提示，HDV是暴发性肝炎和慢性活动性肝炎的病因之一。
