Clewes Jane
North Staffordshire Combined Healthcare NHS Trust, Central Therapies Mental Health, Harplands Hospital, Stoke-on-Trent, Staffordshire, United Kingdom.
Prim Care Companion CNS Disord. 2012;14(1). doi: 10.4088/PCC.11br01218. Epub 2012 Feb 16.
This case report describes a 46-year-old woman with long-standing episodic severe depression (ICD-10 code F33) who discontinued venlafaxine over a 4-week taper after taking the antidepressant for 8 years. Severe discontinuation syndrome was experienced. Panic and relapse of depression occurred 2 months after achieving discontinuation, and the development of tinnitus took place concurrently to the discontinuation. The experience of the tinnitus as a side effect of discontinuation is different from cases reported in the literature in which the tinnitus was experienced when the antidepressant was started and ceased when the antidepressant was stopped. Here, the patient experienced the tinnitus as a discontinuation symptom, and it persisted even after the antidepressant was reintroduced. A review of the literature on antidepressant discontinuation syndrome is also provided.
本病例报告描述了一名46岁患有长期发作性重度抑郁症（ICD - 10编码F33）的女性，她在服用抗抑郁药8年后，经过4周的逐渐减量过程停用了文拉法辛。她经历了严重的停药综合征。停药2个月后出现惊恐发作和抑郁症复发，耳鸣在停药时同时出现。作为停药副作用出现耳鸣的情况与文献报道的病例不同，文献中的病例是在开始服用抗抑郁药时出现耳鸣，并在停药时消失。在此病例中，患者将耳鸣体验为停药症状，即使重新服用抗抑郁药后耳鸣仍持续存在。本文还提供了关于抗抑郁药停药综合征的文献综述。
