从慈竹中分离得到的三萜类和甾体化合物的结构与生物活性测定。

Structure and bioassay of triterpenoids and steroids isolated from Sinocalamus affinis.

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.

出版信息

J Nat Prod. 2012 Jun 22;75(6):1160-6. doi: 10.1021/np300259s. Epub 2012 Jun 12.

DOI:10.1021/np300259s

PMID:22690646

Abstract

Five triterpenoids with a new 25-norfern carbon skeleton (1-5), a lupane triterpenoid (6), and four 20-hydroxyprogesterone acyl esters (7-10), together with 23 known compounds, were isolated from the stem (with skin removed) of Sinocalamus affinis. The absolute configuration of compound 1 was confirmed by single-crystal X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds 1-5 exhibited inhibitory activity against protein tyrosine phosphatase 1B.

摘要

从慈竹茎（去皮）中分离得到了 5 个具有新型 25-降佛尔烷碳骨架的三萜类化合物（1-5）、一个羽扇豆烷三萜类化合物（6）和 4 个 20-羟基孕酮酰酯（7-10），以及 23 个已知化合物。通过利用 Cu Kα 射线的反常散射，使用单晶 X 射线晶体学分析确定了化合物 1 的绝对构型。化合物 1-5 对蛋白酪氨酸磷酸酶 1B 表现出抑制活性。