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海马亚区预测精神分裂症的阳性症状：来自脑形态计量学的初步证据。

Hippocampal subfields predict positive symptoms in schizophrenia: first evidence from brain morphometry.

机构信息

Charité University Medicine, St Hedwig-Krankenhaus, Clinic for Psychiatry and Psychotherapy, Berlin, Germany.

出版信息

Transl Psychiatry. 2012 Jun 12;2(6):e127. doi: 10.1038/tp.2012.51.

DOI:10.1038/tp.2012.51
PMID:22692142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3384220/
Abstract

Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields.

摘要

研究发现，精神分裂症患者的海马解剖结构发生了改变。在本研究中，我们使用 FreeSurfer 测定了 21 例精神分裂症患者的海马亚区体积。高分辨率磁共振成像显示，PANSS 阳性症状评分与双侧海马亚区 CA2/3 及 CA1 体积呈负相关。我们的观察结果为进一步研究精神分裂症中常见的海马异常提供了依据，涉及特定的亚区。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279c/3384220/9ed6cb0a1124/tp201251f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279c/3384220/6f894df8b6b4/tp201251f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279c/3384220/9ed6cb0a1124/tp201251f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279c/3384220/6f894df8b6b4/tp201251f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279c/3384220/9ed6cb0a1124/tp201251f2.jpg

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Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: a combined MRI and 1H-MRS study.精神分裂症中海马体积和 N-乙酰天门冬氨酸浓度缺陷的相互作用：一项联合 MRI 和 1H-MRS 研究。
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Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience.谷氨酸能功能障碍通过短期习惯化缺陷导致多巴胺能表型亢进：异常突显的一种机制。
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