Ito A, Naito M, Naito Y, Watanabe H
Gan. 1982 Apr;73(2):315-22.
The tumorigenicity of hydrogen peroxide (HP) was examined by administering 0.4% HP solution in drinking water to various strains of mice. In C57BL mice, gastric lesions in the forestomach occurred in over 67% of the mice treated with HP for 120 days and duodenal lesions were noted in over 80% of the mice that received HP for 60 days. Gastric lesions were found only in the glandular stomach and duodenal lesions were restricted to the peri-pyloric and proximal part of the duodenum. The lesions in both organs were often multiple. The gastric lesions were composed of erosion and hyperplasia and those in the duodenum were exclusively hyperplasia. In mice given 0.4% and 0.1% HP for 420 to 740 days, 5 and 1% of them, respectively, had duodenal cancer by histological criteria though they did not show any distant metastasis. In the control group, no cancer was noted in the same observation period. The incidence and average numbers of lesions in both the stomach and duodenum after 150 to 210 days of HP intake decreased or fell to zero if HP administration was interrupted for 10 to 30 days. In DBA and BALB mice given 0.4% HP for 90 to 210 days, the incidences of gastric lesions reached 30 and 10% at maximum, respectively, and the incidences of duodenal lesions were 60 to 100% and 40 to 69%, respectively.
通过给不同品系的小鼠饮用含0.4%过氧化氢（HP）的溶液来检测HP的致瘤性。在C57BL小鼠中，饮用HP溶液120天的小鼠，超过67%的前胃出现胃部病变；饮用HP溶液60天的小鼠，超过80%的十二指肠出现病变。胃部病变仅见于腺胃，十二指肠病变局限于十二指肠幽门周围和近端。两个器官的病变通常为多发性。胃部病变由糜烂和增生组成，十二指肠病变则仅为增生。给小鼠饮用0.4%和0.1%的HP溶液420至740天，分别有5%和1%的小鼠经组织学标准诊断为十二指肠癌，尽管它们未显示任何远处转移。在对照组中，在相同观察期内未发现癌症。摄入HP 150至210天后，若中断HP给药10至30天，胃和十二指肠病变的发生率及平均数量会降低或降至零。给DBA和BALB小鼠饮用0.4%的HP溶液90至210天，胃部病变的发生率最高分别达到30%和10%，十二指肠病变的发生率分别为60%至100%和40%至69%。
