金催化的 3-烯-1-炔酰胺的[4+1]环加成反应合成取代的 2-氨基呋喃。
Gold-catalyzed synthesis of substituted 2-aminofurans via formal [4+1]-cycloadditions on 3-en-1-ynamides.
机构信息
Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan, ROC.
出版信息
Chem Commun (Camb). 2012 Jul 21;48(57):7200-2. doi: 10.1039/c2cc33030j. Epub 2012 Jun 12.
PMID:22692387
Abstract
Gold-catalyzed formal [4+1]-cycloadditions between 3-en-1-ynamides 1 and 8-methylquinoline oxide are reported. The success of this reaction relies on a hypothetic oxa-Nazarov cyclization on gold-stabilized allylic cations. Preliminary results on a new 1,2-difunctionalization of 3-en-1-ynamide are also reported.
摘要
报道了金催化的 3-烯-1-炔酰胺 1 和 8-甲基氧化喹啉之间的形式[4+1]-环加成反应。该反应的成功依赖于金稳定的烯丙基阳离子的假设的氧杂-Nazarov 环化。还报道了 3-烯-1-炔酰胺的新 1,2-双官能化的初步结果。
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