Edsell Mark, Bailey Michael, Joe Keith, Millar Ian
At the time of this study, a registrar in Hyperbaric Medicine at The Alfred Hospital, Melbourne, The Heart Hospital Westmoreland Street, London W1G 8PH, England, Phone: +44-(0)20750-43160, Fax: +44-(0)20750-48847, E-mail:
Diving Hyperb Med. 2008 Jun;38(2):139-44.
Calcific uraemic arteriolopathy (CUA), also known as 'calciphylaxis', is a syndrome of ischaemic necrotic ulcers occurring in uraemic patients with end-stage renal failure. It is a debilitating condition with a high morbidity and mortality. Hyperbaric oxygen (HBO) has been used to treat such wounds for many years but evidence of its efficacy is limited.
We aimed to study the efficacy of HBO on the healing of problem ulcers secondary to CUA.
A retrospective case review of all patients with chronic skin ulcers secondary to CUA treated at the Alfred Hospital Hyperbaric Unit from July 1997 to March 2006 (n = 20).
HBO was beneficial in eleven (55%) patients, with six of these (30%) experiencing complete resolution of their ulcers on completion of their treatment. Advancing age was identified as a predictor of a positive outcome (P = 0.02). There was no statistical correlation between the number of HBO treatments and ulcer healing.
HBO can benefit patients with chronic non-healing wounds secondary to CUA, but its precise role remains undefined.
钙化性尿毒症小动脉病（CUA），也被称为“钙过敏”，是终末期肾衰竭尿毒症患者中出现的缺血性坏死性溃疡综合征。它是一种使人虚弱的病症，发病率和死亡率都很高。高压氧（HBO）多年来一直用于治疗此类伤口，但其疗效证据有限。
我们旨在研究高压氧对钙化性尿毒症小动脉病继发问题溃疡愈合的疗效。
对1997年7月至2006年3月在阿尔弗雷德医院高压氧科接受治疗的所有钙化性尿毒症小动脉病继发慢性皮肤溃疡患者进行回顾性病例分析（n = 20）。
高压氧对11名（55%）患者有益，其中6名（30%）患者在完成治疗后溃疡完全愈合。年龄增长被确定为治疗取得积极效果的一个预测因素（P = 0.02）。高压氧治疗次数与溃疡愈合之间无统计学相关性。
高压氧可使钙化性尿毒症小动脉病继发慢性不愈合伤口的患者受益，但其确切作用仍不明确。
