通过金催化引发的级联过程获得富电子芳基稠合六氢喹啉酮。
Access to electron-rich arene-fused hexahydroquinolizinones through a gold-catalysis-initiated cascade process.
机构信息
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7301-4. doi: 10.1002/anie.201203303. Epub 2012 Jun 12.
Abstract
Golden Cascade: With a tethered, electron-rich arene as the internal nucleophile, a gold-catalyzed amide cyclization to an alkyne initiates a cascade process that ends with a Ferrier rearrangement. Electron-rich arene-bearing hexahydroquinolizin-2-ones are formed in good yields and can be converted into indole alkaloids in only a few steps.
摘要
金 cascade：以一个受电子束缚的富电子芳烃作为内亲核试剂，金催化的酰胺环化作用引发炔烃，从而引发级联反应，最终发生 Ferrier 重排。高产率地生成了带有富电子芳烃的六氢喹啉-2-酮，并且只需几步就可以将其转化为吲哚生物碱。
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