Duong Steven, Youssef Joseph, Pimenta Paloma, Aguigam Holly, Zhang Jun, Calantog Alden, Pilch Shira, Masters James G, Wilder-Smith Petra
Beckman Laser Institute, University of California, Irvine, CA 92612, USA.
Lasers Surg Med. 2012 Aug;44(6):482-9. doi: 10.1002/lsm.22039. Epub 2012 Jun 12.
Goal was to evaluate the potential of in vivo optical coherence tomography (OCT) imaging to determine the response of patients with xerostomia to a dry mouth toothpaste versus fluoride toothpaste placebo.
STUDY DESIGN/MATERIALS AND METHODS: Ten subjects with xerostomia participated in this double-blind, crossover, placebo-controlled study. After examination and OCT imaging, subjects used the first product for 15 days, followed by a 7-day washout period, and then they used the second product for 15 days. Data were acquired at 5-day intervals, also before and after the washout.
Visual examination and tongue blade adhesion test did not reflect response to the product. Two imaging-based markers were identified: (i) In OCT images, epithelial thickness increased significantly (P < 0.05) after use of the dry mouth toothpaste, but did not change significantly (P > 0.05) after the use of a fluoride toothpaste and (2) Optical backscattering data showed progressive characteristic changes from baseline with use of the active product.
In this pilot study using in vivo OCT imaging, it was possible to detect and measure oral epithelial response to the dry mouth product versus placebo in patients with xerostomia.
This approach may permit site-specific assessment of xerostomia, individualized treatment planning and monitoring, and sequential mucosal mapping in patients with dry mouth.
目标是评估体内光学相干断层扫描（OCT）成像技术在确定口干症患者对缓解口干牙膏与含氟牙膏安慰剂反应方面的潜力。
研究设计/材料与方法：10名口干症受试者参与了这项双盲、交叉、安慰剂对照研究。在检查和OCT成像后，受试者使用第一种产品15天，随后有7天的洗脱期，然后再使用第二种产品15天。在5天的间隔时间采集数据，包括洗脱期前后的数据。
视觉检查和压舌板粘附试验未反映出对产品的反应。确定了两个基于成像的指标：（i）在OCT图像中，使用缓解口干牙膏后上皮厚度显著增加（P < 0.05），但使用含氟牙膏后无显著变化（P > 0.05）；（ii）光学背散射数据显示，随着活性产品的使用，与基线相比呈现出渐进性特征变化。
在这项使用体内OCT成像的初步研究中，能够检测和测量口干症患者口腔上皮对缓解口干产品与安慰剂的反应。
这种方法可能允许对口干症进行部位特异性评估、个性化治疗计划制定和监测，以及对口干患者进行连续的黏膜图谱绘制。
