Inamdar Padmanabh, Mehta Garima
Department of Surgery, R N T Medical College, Udaipur, Rajastahn India.
Indian J Surg Oncol. 2011 Jun;2(2):118-21. doi: 10.1007/s13193-011-0070-x. Epub 2011 May 6.
Despite advances in management of breast cancer, etiology is still elusive. Diet, obesity and other life style factors have been implicated in its etiology. We assessed the role of obesity and HDL-C levels in patients with rural background in etiology of breast cancer. To know the relation between obesity and incidence of breast cancer in local population. Also to know serum HDL-C level in breast cancer and its correlation with breast cancer. A nested pilot study of 50 breast cancer patients was done and matched with 50 healthy women as controls. Obesity was measured by weight, height, BMI (Body Mass Index), waist circumference (WC), Hip Circumference (HC), WC/HC ratio, and Serum High Density Lipoprotein Cholesterol (HDL-C) was measured in patients and in controls. There was no significant difference in distribution of weight (p = 0.298), height (p = 0.653), BMI (p = 0.459) and WHR (p = 0.052) among cases and controls. HDL-C level was observed to be significantly lower in cases than control group (p = 0.017).Breast cancer patients of pre menopausal age had significantly low Weight (p = 0.037) and BMI (p = 0.011) than post menopausal patients. In our study population only low HDL-C level had significant correlation with breast cancer and none of the other anthropometric measurements were associated with breast cancer. However, large population based case control and cohort studies are needed to identify low serum HDL-C as an independent predictor of increased risk of breast cancer.
尽管乳腺癌的治疗取得了进展，但其病因仍不明确。饮食、肥胖和其他生活方式因素被认为与其病因有关。我们评估了肥胖和高密度脂蛋白胆固醇（HDL-C）水平在农村背景乳腺癌患者病因中的作用。以了解肥胖与当地人群乳腺癌发病率之间的关系。同时了解乳腺癌患者的血清HDL-C水平及其与乳腺癌的相关性。对50例乳腺癌患者进行了一项巢式试点研究，并与50名健康女性作为对照进行匹配。通过体重、身高、体重指数（BMI）、腰围（WC）、臀围（HC）、腰臀比来测量肥胖情况，并对患者和对照者测量血清高密度脂蛋白胆固醇（HDL-C）。病例组和对照组在体重分布（p = 0.298）、身高（p = 0.653）、BMI（p = 0.459）和腰臀比（p = 0.052）方面没有显著差异。观察到病例组的HDL-C水平显著低于对照组（p = 0.017）。绝经前年龄的乳腺癌患者体重（p = 0.037）和BMI（p = 0.011）显著低于绝经后患者。在我们的研究人群中，只有低HDL-C水平与乳腺癌有显著相关性，其他人体测量指标均与乳腺癌无关。然而，需要基于大量人群的病例对照研究和队列研究来确定低血清HDL-C是乳腺癌风险增加的独立预测因素。
