Department of Diagnostic Ultrasound, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.
Int J Endocrinol. 2012;2012:340974. doi: 10.1155/2012/340974. Epub 2012 May 30.
The aim of this study was to evaluate carotid arterial wall elasticity in type 2 diabetes mellitus (T2DM) with microalbuminuria by real-time ultrasound elastography. Two hundred and ten T2DM patients were divided into two groups according to levels of urinary albumin excretion (UAE): T2DM without microalbuminuria (T2DM1 group, 120) and T2DM with microalbuminuria (T2DM2 group, 90). The right common carotid arteries were examined by real-time ultrasound elastography. The strain ratio (SR, blood to arterial wall strain ratio) was calculated by dividing the strain value of the blood by that of the carotid arterial wall. The correlation between SR and general data was analyzed. The mean SR value ± SD of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05). SR was positively and significantly correlated with UAE, HbA1c, and systolic blood pressure (r = 0.456,0.435,0.235, P < 0.05 for all). The mean value ± SD of UAE, HbA1c, 2hPG, BMI, and TC of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05 for all). In conclusion, there is an association between microalbuminuria and carotid arterial wall elasticity in T2DM patients.
本研究旨在通过实时超声弹性成像评估伴有微量白蛋白尿的 2 型糖尿病（T2DM）患者的颈动脉壁弹性。210 例 T2DM 患者根据尿白蛋白排泄率（UAE）水平分为两组：无微量白蛋白尿的 T2DM（T2DM1 组，120 例）和伴有微量白蛋白尿的 T2DM（T2DM2 组，90 例）。使用实时超声弹性成像检查右侧颈总动脉。通过将血液应变值除以颈动脉壁应变值来计算应变比（SR，血液与动脉壁应变比）。分析 SR 与一般数据的相关性。T2DM2 组的平均 SR 值±SD 明显高于 T2DM1 组（P<0.05）。SR 与 UAE、HbA1c 和收缩压呈正相关（r=0.456、0.435、0.235，均 P<0.05）。T2DM2 组的 UAE、HbA1c、2hPG、BMI 和 TC 的平均值±SD 明显高于 T2DM1 组（均 P<0.05）。结论：在 T2DM 患者中，微量白蛋白尿与颈动脉壁弹性之间存在关联。
