Soleimani Effat, Mokhtari-Dizaji Manijhe, Fatouraee Nasser, Saberi Hazhir
Department of Medical Physics, Tarbiat Modares University, Tehran, Iran.
Department of Medical Engineering, Amirkabir University of Technology, Tehran, Iran.
Ultrasonography. 2017 Apr;36(2):144-152. doi: 10.14366/usg.16019. Epub 2016 Sep 20.
The aim of this study was to introduce and implement a noninvasive method to derive the carotid artery pressure waveform directly by processing diagnostic sonograms of the carotid artery.
Ultrasound image sequences of 20 healthy male subjects (age, 36±9 years) were recorded during three cardiac cycles. The internal diameter and blood velocity waveforms were extracted from consecutive sonograms over the cardiac cycles by using custom analysis programs written in MATLAB. Finally, the application of a mathematical equation resulted in time changes of the arterial pressure. The resulting pressures were calibrated using the mean and the diastolic pressure of the radial artery.
A good correlation was found between the mean carotid blood pressure obtained from the ultrasound image processing and the mean radial blood pressure obtained using a standard digital sphygmomanometer (R=0.91). The mean absolute difference between the carotid calibrated pulse pressures and those measured clinically was -1.333±6.548 mm Hg.
The results of this study suggest that consecutive sonograms of the carotid artery can be used for estimating a blood pressure waveform. We believe that our results promote a noninvasive technique for clinical applications that overcomes the reproducibility problems of common carotid artery tonometry with technical and anatomical causes.
本研究的目的是引入并实施一种通过处理颈动脉诊断超声图像直接得出颈动脉压力波形的非侵入性方法。
在三个心动周期内记录了20名健康男性受试者（年龄36±9岁）的超声图像序列。使用用MATLAB编写的自定义分析程序从心动周期内连续的超声图像中提取内径和血流速度波形。最后，应用一个数学方程式得出动脉压力随时间的变化。所得压力使用桡动脉的平均压和舒张压进行校准。
从超声图像处理获得的平均颈动脉血压与使用标准数字血压计获得的平均桡动脉血压之间发现了良好的相关性（R = 0.91）。颈动脉校准脉压与临床测量值之间的平均绝对差为-1.333±6.548 mmHg。
本研究结果表明，颈动脉的连续超声图像可用于估计血压波形。我们相信，我们的结果推动了一种用于临床应用的非侵入性技术，该技术克服了因技术和解剖学原因导致的普通颈动脉张力测量的可重复性问题。
