Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 1701, NY 10032, USA.
Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa.
J Gen Virol. 2012 Sep;93(Pt 9):1952-1958. doi: 10.1099/vir.0.043935-0. Epub 2012 Jun 13.
Human enterovirus 68 (EV-D68) is a historically rarely reported virus linked with respiratory disease. In the past 3 years, a large increase in respiratory disease associated with EV-D68 has been reported, with documented outbreaks in North America, Europe and Asia. In several outbreaks, genetic differences were identified among the circulating strains, indicating the presence of multiple clades. In this report, we analyse archived and novel EV-D68 strains from Africa and the USA, obtained from patients with respiratory illness. Phylogenetic analysis of all EV-D68 sequences indicates that, over the past two decades, multiple clades of the virus have emerged and spread rapidly worldwide. All clades appear to be currently circulating and contributing to respiratory disease.
人类肠道病毒 68 型（EV-D68）是一种历史上很少报道的与呼吸道疾病相关的病毒。在过去的 3 年中，与 EV-D68 相关的呼吸道疾病报告大幅增加，在北美、欧洲和亚洲都有记录的疫情爆发。在几次疫情中，发现循环毒株之间存在遗传差异，表明存在多个分支。在本报告中，我们分析了来自非洲和美国的存档和新型 EV-D68 毒株，这些毒株是从呼吸道疾病患者中获得的。对所有 EV-D68 序列的系统进化分析表明，在过去的二十年中，该病毒的多个分支迅速在全球范围内出现并传播。所有分支目前似乎都在流行，并导致呼吸道疾病。
