Mishra S K, Mishra A, Gugnani H C
Waksman Institute, Rutgers, State University of New Jersey.
Indian J Med Res. 1990 Sep;91:382-5.
Forty strains of Cryptococcus neoformans, 30 of Candida albicans, 24 of C. parapsilosis and 10 strains each of C. tropicalis and C. (Torulopsis) glabrata were examined. A 0.2 per cent solution of concanavalin A (Con A) in phosphate buffered saline and commercial anti-A and anti-B blood grouping sera were used in the whole cell slide agglutination test. All the isolates of Candida species strongly reacted with Con A and over 90 per cent were agglutinated by anti-A and -B blood grouping sera. In contrast, except for one strain, Cryptococcus neoformans did not agglutinate with Con A or blood grouping sera. These findings suggest, on one hand, a fundamental difference in the sugar mosaic of the cell surface components of Cryptococcus neoformans and Candida species, and on the other, presence of similar antigenic determinant(s)/receptors on the cell surface of Candida species and human erythrocytes.
对40株新型隐球菌、30株白色念珠菌、24株近平滑念珠菌以及10株热带念珠菌和光滑念珠菌（原球拟酵母属）进行了检测。在全细胞玻片凝集试验中，使用了在磷酸盐缓冲盐水中的0.2%刀豆球蛋白A（Con A）溶液以及市售抗A和抗B血型血清。所有念珠菌属分离株均与Con A发生强烈反应，超过90%的分离株被抗A和抗B血型血清凝集。相比之下，除了一株新型隐球菌外，其他新型隐球菌均不与Con A或血型血清发生凝集。这些发现一方面表明新型隐球菌和念珠菌属细胞表面成分的糖镶嵌存在根本差异，另一方面表明念珠菌属细胞表面和人类红细胞上存在相似的抗原决定簇/受体。
