Kleinbongard Petra, Baars Theodor, Heusch Gerd
Institut für Pathophysiologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany.
Wien Med Wochenschr. 2012 Jul;162(13-14):302-10. doi: 10.1007/s10354-012-0113-0. Epub 2012 Jun 14.
The present article briefly reviews the processes underlying excitation-contraction coupling in cardiomyocytes and vascular smooth muscle cells, their perturbations during reversible and irreversible myocardial ischemia and reperfusion, notably the pathogenetic role of increased intracellular calcium concentrations, and finally the beneficial effects of calcium antagonists on the impairment of coronary vasomotor tone, on cardiac contractile dysfunction and on myocardial infarction.
本文简要回顾了心肌细胞和血管平滑肌细胞兴奋-收缩偶联的潜在过程、在可逆性和不可逆性心肌缺血及再灌注期间它们所受到的干扰，特别是细胞内钙浓度升高的致病作用，最后阐述了钙拮抗剂对冠状动脉血管舒缩功能障碍、心脏收缩功能障碍及心肌梗死的有益作用。
