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用于治疗心肌缺血再灌注损伤的基于活性氧物种的纳米材料。

Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries.

作者信息

Zhao Tianjiao, Wu Wei, Sui Lihua, Huang Qiong, Nan Yayun, Liu Jianhua, Ai Kelong

机构信息

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410087, China.

Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410008, China.

出版信息

Bioact Mater. 2021 Jun 20;7:47-72. doi: 10.1016/j.bioactmat.2021.06.006. eCollection 2022 Jan.

DOI:10.1016/j.bioactmat.2021.06.006
PMID:34466716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8377441/
Abstract

Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction, but morbidity and mortality of acute myocardial infarction are still high. Reperfusion injuries are inevitable due to the generation of reactive oxygen species (ROS) and apoptosis of cardiac muscle cells. However, many antioxidant and anti-inflammatory drugs are largely limited by pharmacokinetics and route of administration, such as short half-life, low stability, low bioavailability, and side effects for treatment myocardial ischemia reperfusion injury. Therefore, it is necessary to develop effective drugs and technologies to address this issue. Fortunately, nanotherapies have demonstrated great opportunities for treating myocardial ischemia reperfusion injury. Compared with traditional drugs, nanodrugs can effectively increase the therapeutic effect and reduces side effects by improving pharmacokinetic and pharmacodynamic properties due to nanodrugs' size, shape, and material characteristics. In this review, the biology of ROS and molecular mechanisms of myocardial ischemia reperfusion injury are discussed. Furthermore, we summarized the applications of ROS-based nanoparticles, highlighting the latest achievements of nanotechnology researches for the treatment of myocardial ischemia reperfusion injury.

摘要

介入性冠状动脉再灌注策略被广泛用于治疗急性心肌梗死，但急性心肌梗死的发病率和死亡率仍然很高。由于活性氧（ROS）的产生和心肌细胞的凋亡，再灌注损伤不可避免。然而，许多抗氧化和抗炎药物在很大程度上受到药代动力学和给药途径的限制，例如半衰期短、稳定性低、生物利用度低以及治疗心肌缺血再灌注损伤的副作用。因此，有必要开发有效的药物和技术来解决这个问题。幸运的是，纳米疗法在治疗心肌缺血再灌注损伤方面已显示出巨大的潜力。与传统药物相比，纳米药物由于其尺寸、形状和材料特性，可以通过改善药代动力学和药效学特性，有效提高治疗效果并减少副作用。在这篇综述中，我们讨论了ROS的生物学特性和心肌缺血再灌注损伤的分子机制。此外，我们总结了基于ROS的纳米颗粒的应用，突出了纳米技术在治疗心肌缺血再灌注损伤方面的最新研究成果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/9b75c19faf0d/gr16.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/2d52b2db1075/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/edd5f65ee55a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/215d2fab6419/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/78dc432816aa/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/953e723d4acd/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/7ff1b3e0de16/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/98554a771c42/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/54bf69bd15f8/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/336d7f96706d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/4be440d4d64e/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/62a48ef824e6/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/23dcf750c556/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/b90bf0acf7ec/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/3fb88c70dc1e/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/cc008dad330f/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/20edc9634f59/gr15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/8377441/9b75c19faf0d/gr16.jpg

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