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Highly diastereo- and enantioselective synthesis of α-alkyl norstatine derivatives: catalytic asymmetric Mannich reactions of 5H-oxazol-4-ones.

作者信息

Zhao Depeng, Wang Linqing, Yang Dongxu, Zhang Yixin, Wang Rui

机构信息

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000 P.R. China.

出版信息

Angew Chem Int Ed Engl. 2012 Jul 23;51(30):7523-7. doi: 10.1002/anie.201201804. Epub 2012 Jun 13.

DOI:10.1002/anie.201201804
PMID:22696392
Abstract
摘要

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Chem Sci. 2015 Aug 1;6(8):4912-4922. doi: 10.1039/c5sc01614b. Epub 2015 Jun 2.
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1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis.1H-咪唑-4(5H)-酮和噻唑-4(5H)-酮作为不对称催化中新兴的亲核前体。
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