来自便携式（72）硒/（72）砷发生器的放射性砷：当前观点。

Radioarsenic from a portable (72)Se/(72)As generator: a current perspective.

作者信息

Ballard B, Nortier F M, Birnbaum E R, John K D, Phillips D R, Fassbender M E

机构信息

Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

出版信息

Curr Radiopharm. 2012 Jul;5(3):264-70. doi: 10.2174/1874471011205030264.

DOI:10.2174/1874471011205030264

PMID:22697482

Abstract

Positron emission tomography (PET) of slower biological processes calls for the use of longer lived positron emitting radioisotopes. Beyond radionuclide production considerations, practicality and rapidity of subsequent labeling chemistry further limits the selection of radioisotopes with potentially favorable nuclear properties. One additional limitation is the availability of PET radiotracers at the point-of-care with appropriate on-site production methodologies or robust radionuclide generator systems. The positron emitter (72)As (half-life 26 h) is generated via decay of (72)Se (half-life 8.5 d); this pair comprises and excellent generator system for clinical availability of a longer lived PET isotope. Many (72)Se/As generator systems have been introduced utilizing the rich interplay of Se(IV)/Se(VI) and As(III) /As(V) chemical behavior. This paper describes available generator concepts, and briefly outlines some current arsenic labeling methodologies for the introduction of radioarsenic into biomolecules.

摘要

对较慢生物过程进行正电子发射断层扫描（PET）需要使用半衰期更长的正电子发射放射性同位素。除了放射性核素生产方面的考虑，后续标记化学的实用性和快速性进一步限制了具有潜在良好核性质的放射性同位素的选择。另一个限制是在护理点通过适当的现场生产方法或强大的放射性核素发生器系统获得PET放射性示踪剂。正电子发射体（72）As（半衰期26小时）通过（72）Se（半衰期8.5天）的衰变产生；这一对构成了一个出色的发生器系统，可用于临床获得半衰期更长的PET同位素。利用Se(IV)/Se(VI)和As(III)/As(V)化学行为的丰富相互作用，已经引入了许多（72）Se/As发生器系统。本文描述了可用的发生器概念，并简要概述了一些当前用于将放射性砷引入生物分子的砷标记方法。