用于提供作为潜在正电子发射断层显像（PET）成像放射性核素的砷（As）的硒（Se）/砷发生器及硒生产的评估。
Evaluation of Se/As generator and production of Se for supplying As as a potential PET imaging radionuclide.
作者信息
Feng Yutian, Phipps Michael D, Phelps Tim E, Okoye Nkemakonam C, Baumeister Jakob E, Wycoff Donald E, Dorman Eric F, Wooten A Lake, Vlasenko Vladislav, Berendzen Ashley F, Wilbur D Scott, Hoffman Timothy J, Cutler Cathy S, Ketring Alan R, Jurisson Silvia S
机构信息
University of Missouri, Columbia, MO, USA.
University of Washington, Seattle, WA, USA.
出版信息
Appl Radiat Isot. 2019 Jan;143:113-122. doi: 10.1016/j.apradiso.2018.10.026. Epub 2018 Oct 30.
Positron-emitting As is the PET imaging counterpart for beta-emitting As. Its parent, no carrier added (n.c.a.) Se, was produced for a Se/As generator by irradiating an enriched °Ge metal-graphite target via the Ge(α, 2 n)Se reaction. Target dissolution used a fast, environmentally friendly method with 93% radioactivity recovery. Chromatographic parameters of the Se/As generator were evaluated, the eluted n.c.a. As was characterized with a phantom imaging study, and the previously reported trithiol and aryl-dithiol ligand systems were radiolabeled with the separated n.c.a. As in high yield.
发射正电子的砷是发射β射线的砷的正电子发射断层显像（PET）成像对应物。其母体，即无载体添加（n.c.a.）的硒，是通过Ge(α, 2 n)Se反应辐照富集的⁷⁶Ge金属石墨靶来制备用于硒/砷发生器的。靶溶解采用了一种快速、环保且放射性回收率达９３％的方法。评估了硒/砷发生器的色谱参数，用体模成像研究对洗脱的n.c.a.砷进行了表征，并将先前报道的三硫醇和芳基二硫醇配体系统用分离出的n.c.a.砷进行了高产率的放射性标记。
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