Department of Neurology, Post Graduate institute of Medical Education and Research, Chandigarh, India.
Curr Alzheimer Res. 2012 Nov;9(9):1010-29. doi: 10.2174/156720512803569055.
Dementia is a clinical syndrome with abnormal degree of memory loss and impaired ability to recall events from the past often characterized by Alzheimer's disease. The various strategies to treat dementia need validation of novel compounds in suitable animal models for testing their safety and efficacy. These may include novel anti-amnesic drugs derived from synthetic chemistry or those derived from traditional herbal sources. Multiple approaches have been adopted to create reliable animal models ranging from rodents to non-human primates, where the animals are exposed to a predetermined injury or causing genetic ablation across specific regions of brain suspected to affect learning functions. In this review various animal models for Alzheimer's disease and treatment strategies in development of anti dementia drugs are discussed and an attempt has been made to provide a comprehensive report of the latest developments in the field.
痴呆是一种以记忆丧失程度异常和回忆过去事件的能力受损为特征的临床综合征，通常以阿尔茨海默病为代表。治疗痴呆的各种策略需要在合适的动物模型中验证新型化合物，以测试其安全性和疗效。这些化合物可能包括源自合成化学的新型抗健忘药物或源自传统草药来源的药物。已经采用了多种方法来创建可靠的动物模型，从啮齿动物到非人类灵长类动物，这些动物暴露于预定的损伤或导致大脑特定区域的遗传消融，这些区域被怀疑影响学习功能。在这篇综述中，讨论了用于阿尔茨海默病的各种动物模型和开发抗痴呆药物的治疗策略，并试图提供该领域最新发展的综合报告。
