Garcés María Sol, Alústiza Irene, Albajes-Eizagirre Anton, Goena Javier, Molero Patricio, Radua Joaquim, Ortuño Felipe
Department of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Spain.
Colegio de Ciencias Sociales y Humanidades, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
Front Psychiatry. 2021 Dec 20;12:786113. doi: 10.3389/fpsyt.2021.786113. eCollection 2021.
Recent functional neuroimaging studies suggest that the brain networks responsible for time processing are involved during other cognitive processes, leading to a hypothesis that time-related processing is needed to perform a range of tasks across various cognitive functions. To examine this hypothesis, we analyze whether, in healthy subjects, the brain structures activated or deactivated during performance of timing and oddball-detection type tasks coincide. To this end, we conducted two independent signed differential mapping (SDM) meta-analyses of functional magnetic resonance imaging (fMRI) studies assessing the cerebral generators of the responses elicited by tasks based on timing and oddball-detection paradigms. Finally, we undertook a multimodal meta-analysis to detect brain regions common to the findings of the two previous meta-analyses. We found that healthy subjects showed significant activation in cortical areas related to timing and salience networks. The patterns of activation and deactivation corresponding to each task type partially coincided. We hypothesize that there exists a network that serves as a common underlying resource used in a broad range of cognitive processes.
最近的功能神经影像学研究表明，负责时间处理的大脑网络在其他认知过程中也会参与，从而产生了一种假设，即执行一系列跨各种认知功能的任务需要与时间相关的处理。为了检验这一假设，我们分析了在健康受试者中，计时任务和奇异性检测任务执行过程中激活或失活的脑结构是否一致。为此，我们对功能磁共振成像（fMRI）研究进行了两项独立的符号差异映射（SDM）荟萃分析，这些研究评估了基于计时和奇异性检测范式的任务所引发反应的脑源。最后，我们进行了一项多模态荟萃分析，以检测前两项荟萃分析结果中共同的脑区。我们发现，健康受试者在与计时和显著性网络相关的皮质区域表现出显著激活。与每种任务类型相对应的激活和失活模式部分重合。我们假设存在一个网络，作为广泛认知过程中共同使用的潜在资源。
