Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Cancer Cell. 2012 Jun 12;21(6):711-2. doi: 10.1016/j.ccr.2012.05.034.
Hepatocellular carcinoma is the outcome of ongoing cycles of cell death and regeneration in chronic liver disease. In this issue of Cancer Cell, Nikolaou et al. show that the deubiquitinating enzyme CYLD is critical for controlling the balance between hepatocyte loss, regeneration, and malignant progression.
肝细胞癌是慢性肝病中细胞死亡和再生不断循环的结果。在本期《癌细胞》杂志中，Nikolaou 等人表明去泛素化酶 CYLD 对于控制肝细胞丢失、再生和恶性进展之间的平衡至关重要。
