Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland.
Cancer. 2017 May 15;123(10):1695-1698. doi: 10.1002/cncr.30659. Epub 2017 Mar 13.
Intriguingly, recent genomic studies of HNSCC by The Cancer Genome Atlas (TCGA) as well as other groups identified deletions or mutations in TNF-receptor associated factor (TRAF3) and Cylindromatosis (CYLD; Turban Tumor Syndrome) that were previously implicated in NF-κB and anti-viral Interferon responses. Hajek et al find genomic alterations in TRAF3/CYLD define distinct subsets of HPV+ HNSCC with associated activation of transcription factor NF-κB, episomal HPV infection of tumors, and improved survival of patients.
有趣的是，癌症基因组图谱（TCGA）以及其他研究小组最近对 HNSCC 的基因组研究鉴定出肿瘤坏死因子受体相关因子（TRAF3）和圆柱瘤（CYLD；Turbo 肿瘤综合征）的缺失或突变，这些先前与 NF-κB 和抗病毒干扰素反应有关。Hajek 等人发现 TRAF3/CYLD 的基因组改变定义了 HPV+ HNSCC 的不同亚群，与转录因子 NF-κB 的激活、肿瘤的 Epi 状 HPV 感染以及患者生存的改善有关。
