miR‑197‑3p‑induced downregulation of lysine 63 deubiquitinase promotes cell proliferation and inhibits cell apoptosis in lung adenocarcinoma cell lines.

Lung adenocarcinoma (LUAD) is a common cause of cancer-associated mortality. The dysregulation of microRNA (miR) expression has been reported to induce lung carcinogenesis. In the present study, miR‑197‑3p upregulation was detected within LUAD tissues compared with in adjacent noncancerous tissues. The suppression of miR‑197‑3p expression was confirmed to inhibit proliferative ability and induce apoptosis of LUAD cell lines; miR‑197‑3p overexpression within the HBE cell line exhibited opposing effects. Via in silico modeling, western blot analyses and dual‑luciferase assays, it was confirmed that miR‑197‑3p directly targets the lysine 63 deubiquitinase (CYLD) gene. In the present study, the expression of miR‑197‑3p was negatively associated with CYLD mRNA expression within LUAD cell lines. In conclusion, the findings of the present study have provided novel insight into the association of miR‑197‑3p with LUAD proliferation and apoptotic regulation; the miR‑197‑3p/CYLD axis may serve as a novel potential therapeutic target for the treatment of LUAD.