掷骰子以探究 DICER 在肿瘤发生中的作用。
Rolling the dice to discover the role of DICER in tumorigenesis.
机构信息
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, 08908 Catalonia, Spain.
出版信息
Cancer Cell. 2012 Jun 12;21(6):717-9. doi: 10.1016/j.ccr.2012.05.030.
PMID:22698397
Abstract
In an effort to identify the consequences of complete DICER1 loss in tumorigenesis, in this issue of Cancer Cell, Ravi et al. characterize the effects of homozygous deletion of Dicer1. Using an in vivo mouse model, they show that genetic deletion of Dicer1 does not preclude tumor formation.
摘要
为了确定 DICER1 完全缺失在肿瘤发生中的后果，Ravi 等人在本期《癌细胞》中描述了 Dicer1 同源缺失的影响。他们利用体内小鼠模型表明，Dicer1 的遗传缺失并不排除肿瘤的形成。
Zotero 插件