Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka-1217, Bangladesh.
J Ethnopharmacol. 2012 Aug 1;142(3):804-10. doi: 10.1016/j.jep.2012.06.004. Epub 2012 Jun 12.
Impatiens balsamina Linn. (Balsaminaceae), an annual herb locally called "Dopati", is cultivated as an ornamental garden plant in Bangladesh. Flowers of the plant are used in folk medicine to treat lumbago, neuralgia, burns and scalds.
This study evaluated the antinociceptive effect of the methanol extract of I. balsamina flowers (MIB).
The extract was evaluated for antinociceptive activity using chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion and formalin test. To verify the possible involvement of opioid receptor in the central antinociceptive effect of MIB, naloxone was used to antagonize the effect. The effect of MIB on central nervous system (CNS) was also studied using hole cross and open field tests.
MIB demonstrated strong and dose-dependent antinociceptive activity in all the chemical- and heat-induced mice models (p<0.05). These findings imply the involvement of both peripheral and central antinociceptive mechanisms. The use of naloxone confirmed the association of opioid receptors in the central antinociceptive effect. MIB also showed significant central nervous system depressant effect (p<0.05).
This study reported the peripheral and central antinociceptive activity of the flowers of I. balsamina and rationalized the traditional use of the flower in the treatment of different painful conditions.
凤仙花（凤仙花科），一种一年生草本植物，在当地被称为“Dopati”，作为观赏花园植物在孟加拉国种植。该植物的花朵在民间医学中用于治疗腰痛、神经痛、烧伤和烫伤。
本研究评估了凤仙花甲醇提取物（MIB）的镇痛作用。
使用化学和热诱导疼痛模型，如醋酸诱导的扭曲、热板、尾巴浸泡和福马林试验，评估提取物的镇痛活性。为了验证 MIB 对中枢镇痛作用是否涉及阿片受体，使用纳洛酮拮抗其作用。还使用洞交叉和开阔场试验研究 MIB 对中枢神经系统（CNS）的影响。
MIB 在所有化学和热诱导的小鼠模型中均表现出强烈的、剂量依赖性的镇痛活性（p<0.05）。这些发现表明涉及外周和中枢镇痛机制。纳洛酮的使用证实了阿片受体在中枢镇痛作用中的关联。MIB 还显示出显著的中枢神经系统抑制作用（p<0.05）。
本研究报道了凤仙花花朵的外周和中枢镇痛活性，并合理化了传统上使用该花朵治疗各种疼痛状况的做法。
