New York University Langone Medical Center, New York, NY 10016, USA.
Acta Haematol. 2012;128(2):77-82. doi: 10.1159/000338183. Epub 2012 Jun 13.
Primary effusion lymphoma (PEL) is a rare form of non-Hodgkin lymphoma that presents with body cavity effusions. It occurs chiefly in immunodeficient HIV-positive patients. The tumor cells generally express gene sequences of human herpesvirus-8 (HHV-8) and Epstein-Barr virus (EBV). Tumor cells of HIV-negative patients usually express HHV-8 gene sequences, but rarely those of EBV. We report a novel case of PEL in an HIV-negative homosexual male whose tumor cells expressed both HHV-8 and EBV gene sequences and who developed evidence of central nervous system involvement.
原发性渗出性淋巴瘤（PEL）是一种罕见的非霍奇金淋巴瘤，表现为体腔积液。它主要发生在免疫功能低下的 HIV 阳性患者中。肿瘤细胞通常表达人类疱疹病毒 8（HHV-8）和 Epstein-Barr 病毒（EBV）的基因序列。HIV 阴性患者的肿瘤细胞通常表达 HHV-8 基因序列，但很少表达 EBV。我们报告了一例 HIV 阴性同性恋男性的 PEL 新病例，其肿瘤细胞表达 HHV-8 和 EBV 基因序列，并出现中枢神经系统受累的证据。
