Su Yue-Chiu, Chai Chee-Yin, Chuang Shih-Sung, Liao Yung-Liang, Kang Wan-Yi
Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Taiwan.
Kaohsiung J Med Sci. 2008 Oct;24(10):548-52. doi: 10.1016/S1607-551X(09)70015-4.
Primary effusion lymphoma (PEL) is an unusual and rare type of non-Hodgkin's lymphoma characterized by lymphomatous effusion of pleural, pericardial or peritoneal cavities without lymphadenopathy or organomegaly. It is associated with human herpes virus-8 (HHV-8) and occurs most often in immunodeficient patients. We present a case of PEL in a 69-year-old male presenting with pleural effusion and ascites. Fluid aspiration showed a monomorphic population of atypical lymphoid cells, which were medium- to large-sized, with mono- or binucleated hyperchromatic nuclei and a small to moderate amount of basophilic cytoplasm containing cytoplasmic vesicles. Immunohistochemically, the lymphoid cells expressed CD138 and multiple myeloma oncogene 1, were positive for HHV-8, and were monoclonal for immunoglobulin heavy chain gene rearrangement. They were negative for Epstein-Barr virus by in situ hybridization. Unfortunately, the patient died during the first course of chemotherapy with cyclophosphamide, vincristine and prednisone.
原发性渗出性淋巴瘤（PEL）是一种罕见的非霍奇金淋巴瘤，其特征是胸腔、心包腔或腹腔出现淋巴瘤性渗出液，而无淋巴结肿大或器官肿大。它与人类疱疹病毒8型（HHV-8）有关，最常发生于免疫缺陷患者。我们报告一例69岁男性原发性渗出性淋巴瘤患者，表现为胸腔积液和腹水。液体抽吸显示为一群单一形态的非典型淋巴细胞，中等至大细胞大小，单核或双核，核深染，胞质嗜碱性，量少至中等，含有胞质小泡。免疫组化显示，这些淋巴细胞表达CD138和多发性骨髓瘤癌基因1，HHV-8阳性，免疫球蛋白重链基因重排呈单克隆性。原位杂交显示爱泼斯坦-巴尔病毒阴性。不幸的是，患者在环磷酰胺、长春新碱和泼尼松的首个化疗疗程中死亡。
