Von Essen S, Robbins R A, Thompson A B, Rennard S I
Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
J Toxicol Clin Toxicol. 1990;28(4):389-420. doi: 10.3109/15563659009038584.
Organic dust toxic syndrome is a term recently coined to describe a noninfectious, febrile illness associated with chills, malaise, myalgia, a dry cough, dyspnea, headache and nausea which occurs after heavy organic dust exposure. Organic dust toxic syndrome shares many clinical features with acute farmer's lung and other forms of hypersensitivity pneumonitis, including the presence of increased numbers of neutrophils in bronchoalveolar lavage. However, organic dust toxic syndrome differs from acute hypersensitivity pneumonitis in several respects: the chest X-ray does not show infiltrates, severe hypoxemia does not occur, prior sensitization to antigens in the organic dust is not required and there are no known sequelae of physiological significance, such as the recurrent attacks and the pulmonary fibrosis which may be seen with chronic hypersensitivity pneumonitis. Organic dust toxic syndrome is thought to be much more common than farmer's lung. It is important for clinical and investigational purposes that organic dust toxic syndrome be distinguished from acute farmer's lung.
有机粉尘中毒综合征是最近新造的一个术语，用于描述在大量接触有机粉尘后出现的一种非感染性发热疾病，伴有寒战、不适、肌痛、干咳、呼吸困难、头痛和恶心。有机粉尘中毒综合征与急性农民肺及其他类型的过敏性肺炎有许多临床特征相同，包括支气管肺泡灌洗中中性粒细胞数量增加。然而，有机粉尘中毒综合征在几个方面与急性过敏性肺炎不同：胸部X线检查无浸润影，不发生严重低氧血症，无需预先对有机粉尘中的抗原致敏，且不存在已知具有生理意义的后遗症，如慢性过敏性肺炎可能出现的反复发作和肺纤维化。有机粉尘中毒综合征被认为比农民肺更为常见。将有机粉尘中毒综合征与急性农民肺区分开来，对临床和研究目的而言都很重要。
