对映汇聚催化

Mohr Justin T, Moore Jared T, Stoltz Brian M

Department of Chemistry, University of Illinois at Chicago, 845 West Taylor St., Chicago, IL 60607, USA.

The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering California Institute of Technology, 1200 E California Blvd. MC 101-20, Pasadena, CA 91125, USA.

Beilstein J Org Chem. 2016 Sep 16;12:2038-2045. doi: 10.3762/bjoc.12.192. eCollection 2016.

An enantioconvergent catalytic process has the potential to convert a racemic starting material to a single highly enantioenriched product with a maximum yield of 100%. Three mechanistically distinct approaches to effecting enantioconvergent catalysis are identified, and recent examples of each are highlighted. These processes are compared to related, non-enantioconvergent methods.

对映收敛催化过程有潜力将外消旋起始原料转化为单一的高对映体富集产物，最大产率为100%。本文确定了三种实现对映收敛催化的机制不同的方法，并重点介绍了每种方法的最新实例。还将这些过程与相关的非对映收敛方法进行了比较。