Gastroenterology Department, National Medical Center, Hospital de Especialidades, CMN Siglo XXI, IMSS, Mexico City, Mexico.
Ann Hepatol. 2012 Jul-Aug;11(4):564-9.
In recent years there has been a significant increase in the consumption of dietary energy supplements (DES) associated with the parallel advertising against obesity and favoring high physical performance. We present the case and outcome of a young patient who developed acute mixed liver injury (hepatocellular and cholestatic) after ingestion of various "over the counter" products to increase muscle mass and physical performance (NO Xplode®, creatine, L-carnitine, and Growth Factor ATN®). The diagnosis was based on the exclusion of other diseases and liver biopsy findings. The dietary supplement and herbal multivitamins industry is one with the highest growth rates in the market, with annual revenues amounting to billions and constantly lacking scientific or reproducible evidence about the efficacy and/or safety of the offered products. Furthermore, and contrary to popular belief, different forms of injury associated with these natural substances have been documented particularly in the liver, supporting the need of a more strict regulation.
近年来，与对抗肥胖和促进身体机能的并行广告相关联，人们对膳食能量补充剂（DES）的消费显著增加。我们呈现了一位年轻患者的病例和结果，该患者在摄入各种“非处方”产品以增加肌肉质量和身体机能（NO Xplode®、肌酸、左旋肉碱和生长因子 ATN®）后，出现了急性混合性肝损伤（肝细胞和胆汁淤积性）。该诊断基于排除其他疾病和肝活检结果。膳食补充剂和草药多种维生素行业是市场增长率最高的行业之一，年收入达数十亿美元，并且不断缺乏关于所提供产品的功效和/或安全性的科学或可重复的证据。此外，与普遍看法相反，已经记录了与这些天然物质相关的不同形式的损伤，特别是在肝脏中，这支持了更严格监管的必要性。
