Morera-Herreras Teresa, Miguelez Cristina, Aristieta Asier, Ruiz-Ortega José Ángel, Ugedo Luisa
Faculty of Medicine and Dentistry, Department of Pharmacology, University of the Basque Country Leioa, Spain.
Front Pharmacol. 2012 Jun 12;3:110. doi: 10.3389/fphar.2012.00110. eCollection 2012.
There is substantial evidence supporting a role for the endocannabinoid system as a modulator of the dopaminergic activity in the basal ganglia, a forebrain system that integrates cortical information to coordinate motor activity regulating signals. In fact, the administration of plant-derived, synthetic or endogenous cannabinoids produces several effects on motor function. These effects are mediated primarily through the CB(1) receptors that are densely located in the dopamine-enriched basal ganglia networks, suggesting that the motor effects of endocannabinoids are due, at least in part, to modulation of dopaminergic transmission. On the other hand, there are profound changes in CB(1) receptor cannabinoid signaling in the basal ganglia circuits after dopamine depletion (as happens in Parkinson's disease) and following l-DOPA replacement therapy. Therefore, it has been suggested that endocannabinoid system modulation may constitute an important component in new therapeutic approaches to the treatment of motor disturbances. In this article we will review studies supporting the endocannabinoid modulation of dopaminergic motor circuits.
有大量证据支持内源性大麻素系统作为基底神经节中多巴胺能活动调节因子的作用，基底神经节是一个前脑系统，整合皮质信息以协调运动活动调节信号。事实上，给予植物源性、合成或内源性大麻素会对运动功能产生多种影响。这些影响主要通过密集分布在富含多巴胺的基底神经节网络中的CB(1)受体介导，这表明内源性大麻素的运动效应至少部分归因于多巴胺能传递的调节。另一方面，在多巴胺耗竭后（如帕金森病中发生的情况）以及左旋多巴替代治疗后，基底神经节回路中的CB(1)受体大麻素信号传导会发生深刻变化。因此，有人提出内源性大麻素系统调节可能构成治疗运动障碍新疗法的重要组成部分。在本文中，我们将综述支持内源性大麻素对多巴胺能运动回路调节作用的研究。
