阿尔茨海默病和帕金森病中的氧化应激：来自酵母酿酒酵母的见解。
Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae.
机构信息
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal.
出版信息
Oxid Med Cell Longev. 2012;2012:132146. doi: 10.1155/2012/132146. Epub 2012 Jun 3.
Abstract
Alzheimer's (AD) and Parkinson's (PD) diseases are the two most common causes of dementia in aged population. Both are protein-misfolding diseases characterized by the presence of protein deposits in the brain. Despite growing evidence suggesting that oxidative stress is critical to neuronal death, its precise role in disease etiology and progression has not yet been fully understood. Budding yeast Saccharomyces cerevisiae shares conserved biological processes with all eukaryotic cells, including neurons. This fact together with the possibility of simple and quick genetic manipulation highlights this organism as a valuable tool to unravel complex and fundamental mechanisms underlying neurodegeneration. In this paper, we summarize the latest knowledge on the role of oxidative stress in neurodegenerative disorders, with emphasis on AD and PD. Additionally, we provide an overview of the work undertaken to study AD and PD in yeast, focusing the use of this model to understand the effect of oxidative stress in both diseases.
摘要
阿尔茨海默病（AD）和帕金森病（PD）是老年人群中两种最常见的痴呆症病因。这两种疾病都是蛋白质错误折叠疾病，其特征是大脑中存在蛋白质沉积物。尽管越来越多的证据表明氧化应激对神经元死亡至关重要，但它在疾病病因和进展中的确切作用尚未完全理解。酵母酿酒酵母（Saccharomyces cerevisiae）与所有真核细胞（包括神经元）共享保守的生物学过程。这一事实以及简单快速的遗传操作的可能性突出了该生物体作为揭示神经退行性变背后复杂和基本机制的有价值工具。本文总结了氧化应激在神经退行性疾病中的最新知识，重点介绍 AD 和 PD。此外，我们还概述了在酵母中研究 AD 和 PD 所做的工作，重点介绍了使用该模型来理解氧化应激对这两种疾病的影响。
相似文献
1
Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae.阿尔茨海默病和帕金森病中的氧化应激：来自酵母酿酒酵母的见解。
Oxid Med Cell Longev. 2012;2012:132146. doi: 10.1155/2012/132146. Epub 2012 Jun 3.
2
Protein folding diseases and neurodegeneration: lessons learned from yeast.蛋白质折叠疾病与神经退行性变：从酵母中获得的经验教训
Biochim Biophys Acta. 2008 Jul;1783(7):1381-95. doi: 10.1016/j.bbamcr.2008.01.020. Epub 2008 Feb 11.
3
Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways.阿尔茨海默病和帕金森病中的神经元反应：毒性蛋白对细胞内信号通路的影响。
BMC Neurosci. 2015 Oct 23;16:69. doi: 10.1186/s12868-015-0211-1.
4
Harnessing the power of yeast to unravel the molecular basis of neurodegeneration.利用酵母的力量来揭示神经退行性变的分子基础。
J Neurochem. 2013 Nov;127(4):438-52. doi: 10.1111/jnc.12271. Epub 2013 May 8.
5
Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.蛋白质聚集在阿尔茨海默病和帕金森病线粒体功能障碍及神经退行性变中的作用。
Neuromolecular Med. 2003;4(1-2):21-36. doi: 10.1385/NMM:4:1-2:21.
6
Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies.两种常见的地中海植物提取物可改善神经退行性蛋白病的细胞和动物模型。
Neurosci Lett. 2017 Jan 18;638:12-20. doi: 10.1016/j.neulet.2016.11.058. Epub 2016 Dec 2.
7
Amyloid-β peptide-induced cytotoxicity and mitochondrial dysfunction in yeast.淀粉样β肽在酵母中诱导的细胞毒性和线粒体功能障碍。
FEMS Yeast Res. 2015 Sep;15(6). doi: 10.1093/femsyr/fov061. Epub 2015 Jul 6.
8
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.2 型糖尿病帕金森病患者的疾病进展更快与α-突触核蛋白、tau、淀粉样β或血管病理学的增加无关。
Neuropathol Appl Neurobiol. 2021 Dec;47(7):1080-1091. doi: 10.1111/nan.12728. Epub 2021 May 19.
9
Yeast unfolds the road map toward alpha-synuclein-induced cell death.酵母揭示了α-突触核蛋白诱导细胞死亡的路线图。
Cell Death Differ. 2010 May;17(5):746-53. doi: 10.1038/cdd.2009.203. Epub 2009 Dec 18.
10
Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides.用靶向脑苷脂的嵌合阿尔茨海默病/帕金森病肽对钙通透性淀粉样蛋白孔通道进行广泛中和。
Biochim Biophys Acta. 2016 Feb;1862(2):213-22. doi: 10.1016/j.bbadis.2015.11.012. Epub 2015 Dec 2.
引用本文的文献
1
Distinct Effects of PFOS and OBS on Neurotoxicity via PMK-1 Mediated Pathway in .全氟辛烷磺酸和全氟辛基磺酸通过PMK-1介导的途径对神经毒性的不同影响 于……中
Toxics. 2025 Aug 6;13(8):662. doi: 10.3390/toxics13080662.
2
Doxorubicin impairs cognitive function by upregulating AMPAR and NMDAR subunit expression and increasing neuroinflammation, oxidative stress, and apoptosis in the brain.阿霉素通过上调AMPAR和NMDAR亚基表达以及增加大脑中的神经炎症、氧化应激和细胞凋亡来损害认知功能。
Front Pharmacol. 2023 Nov 30;14:1251917. doi: 10.3389/fphar.2023.1251917. eCollection 2023.
3
Elucidation of reactive oxygen species scavenging pathways of norbergenin utilizing DFT approaches.利用密度泛函理论方法阐明降冰片烯宁的活性氧清除途径。
R Soc Open Sci. 2022 Dec 21;9(12):221349. doi: 10.1098/rsos.221349. eCollection 2022 Dec.
4
Analysis of Antioxidant Constituents from and Evaluation of Their Blood-Brain Barrier Permeability.[具体来源]中抗氧化成分的分析及其血脑屏障通透性评估。
Antioxidants (Basel). 2022 Oct 6;11(10):1989. doi: 10.3390/antiox11101989.
5
Potential Role of Ginger ( Roscoe) in the Prevention of Neurodegenerative Diseases.姜（罗斯科）在预防神经退行性疾病中的潜在作用。
Front Nutr. 2022 Mar 18;9:809621. doi: 10.3389/fnut.2022.809621. eCollection 2022.
6
Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders.通过化学功能化增强褪黑素的益处：对多因素神经退行性疾病的可能影响。
Int J Mol Sci. 2021 Oct 27;22(21):11584. doi: 10.3390/ijms222111584.
7
Subcellular Localization of Fad1p in : A Choice at Post-Transcriptional Level?Fad1p在亚细胞中的定位：转录后水平的一种选择？
Life (Basel). 2021 Sep 14;11(9):967. doi: 10.3390/life11090967.
8
NEUROTOXICITY OF METAL MIXTURES.金属混合物的神经毒性
Adv Neurotoxicol. 2021;5:329-364. doi: 10.1016/bs.ant.2020.12.003. Epub 2021 Feb 11.
9
Epalrestat improves motor symptoms by reducing oxidative stress and inflammation in the reserpine induced mouse model of Parkinson's disease.依帕司他通过减轻利血平诱导的帕金森病小鼠模型中的氧化应激和炎症来改善运动症状。
Animal Model Exp Med. 2019 Dec 30;3(1):9-21. doi: 10.1002/ame2.12097. eCollection 2020 Mar.
10
Ginger ( Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence.姜（罗斯科）在预防衰老和退行性疾病方面：当前证据综述
Evid Based Complement Alternat Med. 2019 Aug 20;2019:5054395. doi: 10.1155/2019/5054395. eCollection 2019.
本文引用的文献
1
Methionine-35 of aβ(1-42): importance for oxidative stress in Alzheimer disease.淀粉样β蛋白（1-42）的蛋氨酸-35：对阿尔茨海默病氧化应激的重要性。
J Amino Acids. 2011;2011:198430. doi: 10.4061/2011/198430. Epub 2011 Jun 4.
2
Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases.活性氧/氮物种及其在神经退行性疾病中的功能相关性。
J Neural Transm (Vienna). 2012 Aug;119(8):891-910. doi: 10.1007/s00702-011-0758-7. Epub 2012 Jan 4.
3
Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome.与常染色体隐性帕金森病相关的人类DJ-1/PARK7 L166P蛋白稳定性降低，是由于蛋白酶体直接进行内蛋白水解切割所致。
Biochim Biophys Acta. 2012 Feb;1823(2):524-33. doi: 10.1016/j.bbamcr.2011.11.010. Epub 2011 Dec 8.
4
Yeast: an experimental organism for 21st Century biology.酵母：21 世纪生物学的实验生物。
Genetics. 2011 Nov;189(3):695-704. doi: 10.1534/genetics.111.130765.
5
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.酵母中 Aβ 毒性、内吞运输与阿尔茨海默病风险因素之间的功能联系。
Science. 2011 Dec 2;334(6060):1241-5. doi: 10.1126/science.1213210. Epub 2011 Oct 27.
6
Importance of iron chelation in free radical-induced oxidative stress and human disease.铁螯合在自由基诱导的氧化应激和人类疾病中的重要性。
Curr Pharm Des. 2011;17(31):3460-73. doi: 10.2174/138161211798072463.
7
Lipid peroxidation and neurodegenerative disease.脂质过氧化与神经退行性疾病。
Free Radic Biol Med. 2011 Oct 1;51(7):1302-19. doi: 10.1016/j.freeradbiomed.2011.06.027. Epub 2011 Jun 30.
8
Amyloid precursor protein processing and Alzheimer's disease.淀粉样前体蛋白的加工与阿尔茨海默病。
Annu Rev Neurosci. 2011;34:185-204. doi: 10.1146/annurev-neuro-061010-113613.
9
Advances in metal-induced oxidative stress and human disease.金属诱导的氧化应激与人类疾病的研究进展。
Toxicology. 2011 May 10;283(2-3):65-87. doi: 10.1016/j.tox.2011.03.001. Epub 2011 Mar 23.
10
DJ-1 mediates paraquat-induced dopaminergic neuronal cell death.DJ-1 介导百草枯诱导的多巴胺能神经元细胞死亡。
Toxicol Lett. 2011 Apr 25;202(2):85-92. doi: 10.1016/j.toxlet.2011.01.018. Epub 2011 Feb 21.
Zotero 插件