Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa C.P., Mexico City 09340, Mexico.
Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA.
Int J Mol Sci. 2021 Oct 27;22(21):11584. doi: 10.3390/ijms222111584.
Although melatonin is an astonishing molecule, it is possible that chemistry will help in the discovery of new compounds derived from it that may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes the significant amount of data gathered to date regarding the multiple health benefits of melatonin and related compounds. This review also highlights some of the most recent directions in the discovery of multifunctional pharmaceuticals intended to act as one-molecule multiple-target drugs with potential use in multifactorial diseases, including neurodegenerative disorders. Herein, we discuss the beneficial activities of melatonin derivatives reported to date, in addition to computational strategies to rationally design new derivatives by functionalization of the melatonin molecular framework. It is hoped that this review will promote more investigations on the subject from both experimental and theoretical perspectives.
虽然褪黑素是一种令人惊讶的分子，但有可能通过化学手段发现新的化合物，这些化合物可能会超出我们对其抗氧化保护作用的预期，甚至可能对神经保护作用有帮助。本文简要总结了迄今为止收集到的大量数据，这些数据涉及褪黑素和相关化合物的多种健康益处。本文还强调了在发现多功能药物方面的一些最新进展，这些药物旨在作为一种分子多靶点药物，具有在包括神经退行性疾病在内的多因素疾病中的潜在用途。本文讨论了迄今为止报道的褪黑素衍生物的有益活性，以及通过对褪黑素分子框架进行功能化来合理设计新衍生物的计算策略。希望这篇综述能够从实验和理论两个方面促进更多关于这个主题的研究。
