Ajayi A F, Akhigbe R E, Adewumi O M, Okeleji L O, Mujaidu K B, Olaleye S B
Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Indian J Endocrinol Metab. 2012 Mar;16 Suppl 1(Suppl1):S91-6. doi: 10.4103/2230-8210.94265.
Extracts from various morphological parts of Cryptolepis sanguinolenta are widely used traditionally in folklore medicine in many parts of the world for the management, control, and/or treatment of a plethora of human ailments, including diabetes mellitus. In order to scientifically appraise some of the ethnomedical uses of Cryptolepis sanguinolenta, the present study was undertaken to investigate its influence at varying doses on intestinal glucose absorption and transport in relation to its hypoglycemic and hypolipidemic effects in rat experimental paradigms.
The animals used were divided into four groups. Control animals received 2 ml of distilled water, while treated groups received 50, 150, and 250 mg/kg bw of Cryptolepis sanguinolenta extract per oral respectively daily for 21 days.
Cryptolepis sanguinolenta led to a significant decrease in glucose transport and absorption. It also caused significant reductions in plasma glucose, total cholesterol, triglyceride, and LDL cholesterol. Biochemical changes observed were suggestive of dose dependence. Histopathological studies also showed increased sizes of β cells of the pancreas.
The findings in these normoglycemic laboratory animals suggest that Cryptolepis sanguinolenta has hypoglycemic and hypolipidemic activities, possibly by reducing glucose absorption and transport, and enhancing the structural and functional abilities of the β cells. This is the first study to report the effect of Cryptolepis sanguinolenta on intestinal glucose absorption. This effect could be attributed to its major bioactive principle, cryptolepine, an indoloquinoline alkaloid. This study thus lends credence to the use of Cryptolepis sanguinolenta in the management of diabetes mellitus.
在世界许多地区的民间医学中，羊角拗（Cryptolepis sanguinolenta）各形态部位的提取物传统上被广泛用于管理、控制和/或治疗多种人类疾病，包括糖尿病。为了科学评估羊角拗的一些民族医学用途，本研究旨在探讨其在大鼠实验模型中不同剂量对肠道葡萄糖吸收和转运的影响及其降血糖和降血脂作用。
所用动物分为四组。对照组动物给予2 ml蒸馏水，而治疗组分别每天口服50、150和250 mg/kg体重的羊角拗提取物，持续21天。
羊角拗导致葡萄糖转运和吸收显著降低。它还使血浆葡萄糖、总胆固醇、甘油三酯和低密度脂蛋白胆固醇显著降低。观察到的生化变化表明存在剂量依赖性。组织病理学研究还显示胰腺β细胞体积增大。
这些血糖正常的实验动物的研究结果表明，羊角拗具有降血糖和降血脂活性，可能是通过减少葡萄糖吸收和转运，并增强β细胞的结构和功能能力。这是第一项报道羊角拗对肠道葡萄糖吸收作用的研究。这种作用可能归因于其主要生物活性成分羊角拗碱，一种吲哚喹啉生物碱。因此，本研究为羊角拗用于糖尿病管理提供了依据。
