Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Nat Prod Res. 2013 Apr;27(8):753-60. doi: 10.1080/14786419.2012.698410. Epub 2012 Jun 18.
Bioassay-directed isolation of Feroniella lucida stem bark yielded three new apotirucallane triterpenoids named feroniellides C-E. The structures of the new compounds were established by extensive analysis of spectroscopic data. Of triterpenoids examined, feroniellides D and E revealed anticancer activity against KB and HeLa cells with IC50 values in range of 3.4-14.2 µg mL(-1), which are significantly more potent than feroniellides A-C (IC50 25.5-60.0 µg mL(-1)). The present investigation suggests that an isovalerate moiety in feroniellides D and E is possibly associated with exerting cytotoxicity against cancer cells.
生物活性导向分离秀丽榕茎皮得到三个新的无翼杯烷三萜类化合物，命名为秀丽榕内酯 C-E。通过对光谱数据的广泛分析确定了新化合物的结构。在所检查的三萜中，秀丽榕内酯 D 和 E 对 KB 和 HeLa 细胞表现出抗癌活性，IC50 值在 3.4-14.2μg/mL 范围内，明显比秀丽榕内酯 A-C（IC50 25.5-60.0μg/mL）更有效。本研究表明，秀丽榕内酯 D 和 E 中的异戊酸部分可能与对癌细胞的细胞毒性有关。
