病毒感染中的组蛋白去乙酰化酶。
Histone deacetylases in viral infections.
出版信息
Clin Epigenetics. 2010 Sep;1(1-2):13-24. doi: 10.1007/s13148-010-0003-5. Epub 2010 May 30.
Abstract
Chromatin remodeling and gene expression are regulated by histone deacetylases (HDACs) that condense the chromatin structure by deacetylating histones. HDACs comprise a group of enzymes that are responsible for the regulation of both cellular and viral genes at the transcriptional level. In mammals, a total of 18 HDACs have been identified and grouped into four classes, i.e., class I (HDACs 1, 2, 3, 8), class II (HDACs 4, 5, 6, 7, 9, 10), class III (Sirt1-Sirt7), and class IV (HDAC11). We review here the role of HDACs on viral replication and how HDAC inhibitors could potentially be used as new therapeutic tools in several viral infections.
摘要
组蛋白去乙酰化酶（HDACs）通过去乙酰化组蛋白来调节染色质结构，从而调节染色质重塑和基因表达。HDACs 是一组酶，负责在转录水平上调节细胞和病毒基因。在哺乳动物中，已经鉴定出总共 18 种 HDACs，并分为四类，即 I 类（HDACs 1、2、3、8）、II 类（HDACs 4、5、6、7、9、10）、III 类（Sirt1-Sirt7）和 IV 类（HDAC11）。在这里，我们综述了 HDACs 在病毒复制中的作用，以及 HDAC 抑制剂如何可能成为几种病毒感染的新治疗工具。
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