Department of Pediatric Urology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
J Urol. 2012 Aug;188(2):594-7. doi: 10.1016/j.juro.2012.04.023. Epub 2012 Jun 15.
Assisted reproductive technologies are increasingly being used to treat infertility. Male adolescents with cancer are particularly encouraged to bank semen to preserve fertility before beginning chemotherapy or radiotherapy. We evaluated the feasibility of semen preservation in 12 to 17-year-old patients with cancer.
We retrospectively collected data from the sperm banking database at our institution for the years 1995 to 2009. Outcomes measured were histological diagnosis, success rate, sperm concentration and sample volume.
A total of 180 patients with a mean age of 16.1 years (range 13.2 to 17.9) were referred for cryopreservation during the study period. Underlying diagnoses included lymphoma (64 patients), leukemia (50), bone tumors (18), testicular tumors (13), soft tissue sarcoma (13), brain tumor (6), germ cell tumors (6) and other cancers (10). Of the patients 119 (66%) successfully banked sperm. A total of 26 patients did not attend their appointment. Of those who attended 15 (10%) were unable to provide a sample and 20 (13%) had azoospermia. A total of 20 patients died after banking sperm and their specimens were subsequently destroyed.
Cryopreservation of semen of acceptable quality for future use in assisted conception is feasible for most adolescents from age 13 years onward.
辅助生殖技术越来越多地用于治疗不孕症。特别鼓励男性青少年在开始化疗或放疗前储存精液以保留生育能力。我们评估了在 12 至 17 岁癌症患者中进行精液保存的可行性。
我们回顾性地收集了我们机构的精子库数据库在 1995 年至 2009 年的数据。测量的结果是组织学诊断、成功率、精子浓度和样本量。
在研究期间，共有 180 名平均年龄为 16.1 岁（范围 13.2 至 17.9）的患者因冷冻保存而被转介。基础诊断包括淋巴瘤（64 例）、白血病（50 例）、骨肿瘤（18 例）、睾丸肿瘤（13 例）、软组织肉瘤（13 例）、脑肿瘤（6 例）、生殖细胞瘤（6 例）和其他癌症（10 例）。在这些患者中，有 119 名（66%）成功地储存了精子。共有 26 名患者未参加预约。在参加预约的患者中，有 15 名（10%）无法提供样本，有 20 名（13%）患有无精子症。共有 20 名患者在储存精子后死亡，随后他们的标本被销毁。
对于大多数 13 岁以上的青少年来说，冷冻保存可用于辅助受孕的质量可接受的精液是可行的。
