Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women's Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
Am J Obstet Gynecol. 2012 Aug;207(2):140.e1-6. doi: 10.1016/j.ajog.2012.05.003. Epub 2012 May 8.
Decreased levels of serum placenta growth factor (PlGF) are associated with preeclampsia. We sought to determine whether serum and placental levels of PlGF (sPlGF and pPlGF) are associated with preeclampsia and whether there is a correlation between serum and placental PlGF levels.
These analyses were part of a larger, prospective, case-control study. Cases were women with preeclampsia. Controls were women without preeclampsia who delivered at term. Analyses included nonparametric tests to compare medians, logistic regression to estimate odds, and calculation of correlation coefficients.
Twenty-four cases (10 preterm, 14 term) were compared with 14 controls. Median levels of PlGF were significantly lower in cases than controls (pPlGF: 232.6 vs 363.4 pg/mL, P = .02; sPlGF: 85.5 vs 274.4 pg/mL, P < .001). Serum and placental PlGF were correlated (overall: 39%, P = .006; cases with preterm preeclampsia and growth restriction: 87%, P = .02).
Serum and placental PlGF are independently associated with preeclampsia and correlated with each other.
血清胎盘生长因子（PlGF）水平降低与子痫前期有关。我们旨在确定血清和胎盘 PlGF（sPlGF 和 pPlGF）水平是否与子痫前期有关，以及血清和胎盘 PlGF 水平之间是否存在相关性。
这些分析是一项更大的前瞻性病例对照研究的一部分。病例为子痫前期患者。对照组为无子痫前期且足月分娩的妇女。分析包括非参数检验比较中位数、逻辑回归估计比值比以及计算相关系数。
24 例（10 例早产，14 例足月）与 14 例对照组进行比较。病例组的 PlGF 水平明显低于对照组（pPlGF：232.6 与 363.4 pg/mL，P=0.02；sPlGF：85.5 与 274.4 pg/mL，P<0.001）。血清和胎盘 PlGF 呈正相关（总体：39%，P=0.006；早产伴生长受限的子痫前期病例：87%，P=0.02）。
血清和胎盘 PlGF 与子痫前期独立相关，且彼此相关。
