*Ophthalmology Department, Fondation Ophtalmologique Adolphe de Rothschild †Ophthalmology Department, Hôpital Bichat-Claude Bernard ‡CRICM, Cogimage, Université Pierre et Marie Curie, UMR 7225, CNRS, INSERM, Paris §Ophthalmology Department, Angers University Hospital, Angers, France ∥Glostrup University Hospital, Copenhagen, Denmark.
J Glaucoma. 2014 Jan;23(1):23-32. doi: 10.1097/IJG.0b013e31825c10dc.
Our study aimed at investigating the extent to which saccadic eye movements are disrupted in patients with primary open-angle glaucoma (POAG). This approach followed upon the discovery of differences in the eye-movement behavior of POAG patients during the exploration of complex visual scenes.
The eye movements of 8 POAG patients and 4 healthy age-matched controls were recorded. Four of the patients had documented visual field scotoma, and 4 had no identifiable scotoma on visual field testing. The eye movements were monitored as the observers watched static and kinetic targets. The gain, latency, and velocity-peak latency of the saccades recorded were then analyzed.
In POAG patients, with abnormal visual fields, watching a static target, the saccades were delayed and their accuracy was reduced, compared with those of normal observers. In POAG patients, with normal and abnormal visual fields, watching a kinetic target, a task involving precise motion analysis, the latency and accuracy of the saccades were impaired, compared with those of normal observers.
Our findings suggest that POAG alters saccade programming and execution particularly in the case of moving targets.
本研究旨在探讨原发性开角型青光眼（POAG）患者的眼球跳动（扫视）运动在何种程度上受到干扰。这一方法是基于对 POAG 患者在探索复杂视觉场景时的眼球运动行为差异的发现。
记录了 8 名 POAG 患者和 4 名年龄匹配的健康对照组的眼球运动。其中 4 名患者的视野存在明确的盲点，而 4 名患者在视野测试中没有发现可识别的盲点。当观察者观察静态和动态目标时，监测眼球运动。然后分析记录的扫视的增益、潜伏期和速度峰值潜伏期。
在视野异常的 POAG 患者中，观察静态目标时，与正常观察者相比，扫视延迟且准确性降低。在视野正常和异常的 POAG 患者中，观察动态目标（涉及精确运动分析的任务）时，扫视的潜伏期和准确性受到损害。
我们的发现表明，POAG 改变了扫视的编程和执行，特别是在移动目标的情况下。
