Cerulli Angelica, Cesareo Massimo, Ciuffoletti Elena, Montanaro Maria Lucia, Mancino Raffaele, Mirisola Concetta, Sorge Roberto, Cedrone Claudio, Nucci Carlo, Cerulli Luciano
* These authors contributed equally to this work.
Eur J Ophthalmol. 2014 May-Jun;24(3):358-63. doi: 10.5301/ejo.5000397. Epub 2013 Nov 25.
To assess eye movements pattern during reading process in patients with primary open-angle glaucoma (POAG) using a microperimeter.
Thirty-two patients with POAG at early and moderate stage, according to Glaucoma Staging System 2, and 34 healthy age- and sex-matched subjects were included in the study. Reading speed and accuracy were previously evaluated with specific tests adjusted for age. In addition, all participants performed a reading test with Microperimeter Nidek MP1. Ocular movements during the reading process were recorded and values of maximum and minimum eye movements along the horizontal (Xmax and Xmin) and vertical (Ymax and Ymin) axis and mean ocular movement speed were provided by the MP1.
There were significant differences between patients with and without POAG in terms of Xmax and Ymax eye movement values (4.75 ± 2.57 versus 3.38 ± 0.67, p = 0.003; and 4.39 ± 1.43 versus 3.34 ± 0.52, p<0.001, respectively). These differences were significant even comparing only stage 1 patients to controls. There were no significant differences in Xmin and Ymin values and mean ocular movement speed between the 2 groups.
The study showed significant differences in eye movements pattern in patients with POAG during the reading test performed with the MP1 when compared to the control group. These alterations may be partly the consequence of the neurodegenerative process of the central visual pathway in glaucoma.
使用微视野计评估原发性开角型青光眼（POAG）患者阅读过程中的眼动模式。
根据青光眼分期系统2，纳入32例早期和中期POAG患者以及34例年龄和性别匹配的健康受试者。先前已通过针对年龄调整的特定测试评估了阅读速度和准确性。此外，所有参与者均使用尼德克MP1微视野计进行阅读测试。记录阅读过程中的眼动情况，MP1提供沿水平轴（Xmax和Xmin）和垂直轴（Ymax和Ymin）的最大和最小眼动值以及平均眼动速度。
POAG患者和非POAG患者在Xmax和Ymax眼动值方面存在显著差异（分别为4.75±2.57与3.38±0.67，p = 0.003；以及4.39±1.43与3.34±0.52，p<0.001）。即使仅将1期患者与对照组进行比较，这些差异也很显著。两组在Xmin和Ymin值以及平均眼动速度方面无显著差异。
研究表明，与对照组相比，POAG患者在使用MP1进行阅读测试时眼动模式存在显著差异。这些改变可能部分是青光眼中央视觉通路神经退行性变过程的结果。
