Division of Diabetology, Paolo Borsellino Hospital, Marsala, Italy.
Endocrine. 2013 Feb;43(1):108-11. doi: 10.1007/s12020-012-9718-8. Epub 2012 Jun 16.
The association between celiac disease and type 1 diabetes mellitus is well known. Up to now, celiac disease prevalence in children and adults with type 1 diabetes in Sicily has not been reported. The aim of this study was to assess the prevalence of celiac disease in patients with type 1 diabetes mellitus who come from a defined geographical area in western Sicily and to investigate the clinical features of these subjects. The records of 492 consecutive patients with type 1 diabetes mellitus referred in a period of 5 years were analyzed. During the period of the survey, out of 492 patients with type 1 diabetes, 22 (4.5 %) had a previous diagnosis of celiac disease. There were 14 females and 8 males; these patients showed a mean age of 13 years at diabetes onset. Diagnosis of celiac disease was often simultaneous or subsequent to that of diabetes. Autoimmune thyroiditis was coexisting in 8 patients (36 %). Our data confirm, in a Sicilian population, the not unusual association between celiac disease and type 1 diabetes, although prevalence rate is lower than in others Italian studies. Autoimmune thyroiditis is present with high prevalence in these patients. Celiac disease diagnosis often followed onset of type 1 diabetes, particularly in female subjects with a young age at diabetes onset; therefore, in these subjects, an active search for the presence of celiac disease is warranted for many years after appearance of diabetes.
乳糜泻与 1 型糖尿病之间的关联是众所周知的。迄今为止，西西里岛尚未报告过 1 型糖尿病患儿和成人的乳糜泻患病率。本研究旨在评估来自西西里岛西部一个特定地理区域的 1 型糖尿病患者中乳糜泻的患病率，并调查这些患者的临床特征。对 5 年内就诊的 492 例连续 1 型糖尿病患者的记录进行了分析。在调查期间，492 例 1 型糖尿病患者中有 22 例（4.5%）曾被诊断为乳糜泻。这些患者中有 14 名女性和 8 名男性；他们在糖尿病发病时的平均年龄为 13 岁。乳糜泻的诊断通常与糖尿病同时或之后发生。8 例患者（36%）合并自身免疫性甲状腺炎。我们的数据证实，在西西里人群中，乳糜泻与 1 型糖尿病之间存在不常见的关联，尽管患病率低于其他意大利研究。这些患者中自身免疫性甲状腺炎的患病率很高。乳糜泻的诊断通常在 1 型糖尿病发病后出现，特别是在发病年龄较小的女性患者中；因此，对于这些患者，在糖尿病出现后的多年内，需要积极寻找乳糜泻的存在。
