Amit Akirov, Beilinson Campus, Rabin Medical Center, Petach-Tikva 49100, Israel.
World J Diabetes. 2015 Jun 10;6(5):707-14. doi: 10.4239/wjd.v6.i5.707.
The co-occurrence of celiac disease (CD) and type 1 diabetes (T1DM) has been reported as 5-7 times more prevalent than CD alone. The clinical presentation and natural history of CD in patients with T1DM may vary considerably. Less than 10% of patients with T1DM and CD show gastrointestinal symptoms. Therefore, experts support screening for CD in T1DM patients, though there is no consensus as to the recommended frequency of screening. When stratified by time since CD diagnosis, longer follow-up and coexistence of CD are associated with significant increased risk of diabetic associated morbidity and mortality. Early CD diagnosis and treatment with a gluten-free diet are essential.
乳糜泻（CD）和 1 型糖尿病（T1DM）同时发生的情况比单独发生 CD 的情况要常见 5-7 倍。在 T1DM 患者中，CD 的临床表现和自然病程可能有很大差异。不到 10%的 T1DM 和 CD 患者有胃肠道症状。因此，专家支持对 T1DM 患者进行 CD 筛查，尽管对于推荐的筛查频率尚未达成共识。按 CD 诊断后时间分层，随访时间更长和 CD 共存与糖尿病相关发病率和死亡率的显著增加风险相关。早期 CD 诊断和无麸质饮食治疗至关重要。
